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GenomicsGenome-wide analyses of the DRB response of the histone H3 Lys36 methylation state, as well as Ash1l occupancy in mouse embryonic stem cells.
Using wild type and Ash1l ?SET mutant embryonic stem cells, against a prevalent notion, here we report di-,tri-methylation of histone H3 Lys36 occur independently of ongoing transcription. Ash1l ?SET mutant shows the impaired methylation levels in broad range of genome. Intriguingly, data implicate ...
ORGANISM(S): Mus musculus 
2013-11-20 | E-GEOD-48421 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of Ash1l mutant mouse embryonic stem cells.
Using wild type and Ash1l deltaSET mutant embryonic stem cells, here we report differences of gene expression pattern under undifferentiated state and differentiated state. Interestingly, gene expression changes are frequently observed in a subset of gene group that is regulated by Polycomb group pr...
ORGANISM(S): Mus musculus 
2013-11-20 | E-GEOD-48419 | biostudies-arrayexpress
ProteomicsProteomic analysis of FK506 treated cancer cells
Hs578T cells were treated with FK506 for 3h and 12h, and proteomics analysis performed to identify proteins affected by FK506 treatment
ORGANISM(S): Homo Sapiens (human) 
2024-12-30 | PXD042833 | JPOST Repository
MetabolomicsOmics data integration allows the identification of an idiopathic Parkinson’s disease signature
The vast majority of Parkinson’s disease cases are idiopathic. Unclear ethiology and multifactorial nature complicate the comprehension of disease pathogenesis. Identification of early transcriptomic and metabolic alterations consistent across different idiopathic Parkinson’s disease (IPD) patients ...
2026-03-16 | MTBLS7740 | MetaboLights
ProteomicsSKP1A-mediated degradation of PRC2 triggers activation of Polycomb-silenced genes
Polycomb group (PcG) proteins are evolutionarily conserved repressors of developmental genes. Paradoxically, the same PcG proteins also play roles in gene activation via mechanisms that are not yet fully understood. Here, to reveal the function of S-phase kinase-associated protein 1A (SKP1A), an ess...
ORGANISM(S): Mus Musculus (mouse) 
2025-08-27 | PXD047552 | JPOST Repository
ProteomicsSKP1A-mediated degradation of PRC2 triggers activation of Polycomb-silenced genes
Polycomb group (PcG) proteins are evolutionarily conserved repressors of developmental genes. Paradoxically, the same PcG proteins also play roles in gene activation via mechanisms that are not yet fully understood. Here, to reveal the function of S-phase kinase-associated protein 1A (SKP1A), an ess...
ORGANISM(S): Mus Musculus (mouse) 
2025-08-27 | PXD047556 | JPOST Repository
ProteomicsPCGF1-PRC1 safeguards recovery of nucleosome positioning during S-phase to ensure early hematopoiesis
Polycomb repressive complexes 1 and 2 (PRC1 and 2) repress lineage inappropriate genes during development to maintain proper cellular identities. To reveal the function of a variant PRC1 containing PCGF1 (PCGF1-PRC1), we prepared PCGF1 interacting proteins by immunoprecipitation and characterized th...
ORGANISM(S): Mus Musculus (mouse) 
2023-05-13 | PXD033883 | JPOST Repository
UnknownAzithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.
Not available
S-EPMC7884931 | biostudies-literature
UnknownTocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.
Not available
S-EPMC8084355 | biostudies-literature
UnknownCasirivimab and imdevimab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.
Not available
S-EPMC8830904 | biostudies-literature
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