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TranscriptomicsA systematic search for transgenerational effect of drug exposure to adult males using a novel Drosophila model
Drosophila melanogaster adult flies fed on food containing 16 mg/ml of pentylenetetrazole (PTZ) in the food show a hyperkinetic behavior within 24 hours. Half of that concentration, i.e., 8 mg/ml, of PTZ, if fed for seven days, though doesn’t cause seizure-like behavior, results in a decreased climb...
ORGANISM(S): Drosophila melanogaster 
2009-03-25 | E-GEOD-15136 | biostudies-arrayexpress
TranscriptomicsChronic Pentylenetetrazol treatment induced successive gene expression changes in Drosophila head
Pentylenetetrazol (PTZ)-induced kindling in rodents is an established model of epileptogenesis. The molecular basis of the associated long-term plasticity is however not clear. Further, rodent models of kindling plasticity are not amenable to large-scale screening of compounds for identifying antiep...
ORGANISM(S): Drosophila melanogaster 
2007-10-01 | E-GEOD-7120 | biostudies-arrayexpress
TranscriptomicsControl cDNA microarray profiles of Drosophila head
In the process of developing a biological systems model of kindling-like plasticity in the fruit fly, we performed a control gene expression profiling analysis in which RNA isolated from different pools of heads of wild-type flies grown on normal food (NF) were compared between themselves using cDNA...
ORGANISM(S): Drosophila melanogaster 
2007-10-01 | E-GEOD-7037 | biostudies-arrayexpress
TranscriptomicsGene expression changes in Drosophila head secondary to gabapentin treatment during Pentylenetetrazole withdrawal.
Drosophila melanogaster adult flies fed on normal food (NF) containing 16 mg/ml of pentylenetetrazole (PTZ) in the food show a hyperkinetic behavior within 24 hours. Half of that concentration, i.e., 8 mg/ml, of the PTZ, if fed for seven days, though doesn’t cause seizure-like behavior, results in a...
ORGANISM(S): Drosophila melanogaster 
2008-05-03 | E-GEOD-10985 | biostudies-arrayexpress
TranscriptomicsGene expression changes in Drosophila head secondary to ethosuximide treatment during Pentylenetetrazole withdrawal.
Drosophila melanogaster adult flies fed on normal food (NF) containing 16 mg/ml of pentylenetetrazole (PTZ) in the food show a hyperkinetic behavior within 24 hours. Half of that concentration, i.e., 8 mg/ml, of the PTZ, if fed for seven days, though doesn’t cause seizure-like behavior, results in a...
ORGANISM(S): Drosophila melanogaster 
2008-05-03 | E-GEOD-10984 | biostudies-arrayexpress
TranscriptomicsGene expression changes in Drosophila head secondary to sodium valproate treatment during Pentylenetetrazole withdrawal.
Drosophila melanogaster adult flies fed on normal food (NF) containing 16 mg/ml of pentylenetetrazole (PTZ) in the food show a hyperkinetic behavior within 24 hours. Half of that concentration, i.e., 8 mg/ml, of the PTZ, if fed for seven days, though doesn’t cause seizure-like behavior, results in a...
ORGANISM(S): Drosophila melanogaster 
2008-05-03 | E-GEOD-10986 | biostudies-arrayexpress
TranscriptomicsGene expression changes in Drosophila head secondary to vigabatrin treatment during Pentylenetetrazole withdrawal.
Drosophila melanogaster adult flies fed on normal food (NF) containing 16 mg/ml of pentylenetetrazole (PTZ) in the food show a hyperkinetic behavior within 24 hours. Half of that concentration, i.e., 8 mg/ml, of the PTZ, if fed for seven days, though doesn’t cause seizure-like behavior, results in a...
ORGANISM(S): Drosophila melanogaster 
2008-05-03 | E-GEOD-10987 | biostudies-arrayexpress
TranscriptomicsGene expression changes in Drosophila head secondary to levetiracetam treatment during Pentylenetetrazole withdrawal.
Drosophila melanogaster adult flies fed on normal food (NF) containing 16 mg/ml of pentylenetetrazole (PTZ) in the food show a hyperkinetic behavior within 24 hours. Half of that concentration, i.e., 8 mg/ml, of the PTZ, if fed for seven days, though doesn’t cause seizure-like behavior, results in a...
ORGANISM(S): Drosophila melanogaster 
2008-05-03 | E-GEOD-10988 | biostudies-arrayexpress
TranscriptomicsChronic Pentylenetetrazol withdrawal induced successive gene expression changes in Drosophila head
Kindling induced by Pentylenetetrazol is an established rodent model of epileptogenesis. The molecular basis of the long-term plasticity involved is however not clear. In addition, rodent models of kindling plasticity are not useful for large-scale screening of compounds to identify antiepileptogeni...
ORGANISM(S): Drosophila melanogaster 
2007-10-01 | E-GEOD-7156 | biostudies-arrayexpress
TranscriptomicsTelomerase inhibitor TMPyP4 induced gene expression
The effect of TMPyP4, the well established anticancer telomerase inhibitor on genome wide expression of genes was investigated Keywords: Time course Cells were treated with TMPyP4 for either 24 or 48 hours before RNA isolation.Untreated cells were taken as controls and the TMPyP4 treated cells as tr...
ORGANISM(S): Homo sapiens 
2010-06-10 | E-GEOD-5226 | biostudies-arrayexpress
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