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ProteomicsTargeted degradation of MDM2 overcomes feedback regulation of p53 signaling in Merkel cell carcinoma models.
This study explores the efficacy of MDM2 degraders, KTX-049 and KT-253, in treating Merkel cell carcinoma (MCC), an aggressive skin cancer. MCC tumors often exhibit clonal integration of Merkel cell polyomavirus, with virus-positive (MCCP) and virus-negative (MCCN) tumors showing distinct molecular ...
ORGANISM(S): Homo sapiens (Human) 
2026-03-31 | PXD065666 | Pride
UnknownAssessment of antibiotic utilization patterns in an Indian Level-1 Trauma Center: a pilot study exploring days of antibiotic spectrum coverage and defined daily doses using WHO AWaRe classification trends.
Not available
S-EPMC12304517 | biostudies-literature
ProteomicsUltra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling
Regulatory protein phosphorylation controls nearly every normal and pathophysiological signaling system in eukaryotic cells. Despite great advances in mass spectrometry based-proteomics, the total number, localization and site-specific stoichiometry of this post-translational modification (PTM) are ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-28 | MSV000080701 | MassIVE
ProteomicsCell-type and brain-region resolved mouse brain proteome
To understand the complexity of the brain, connectome and transcriptome maps of high resolution are being generated, but an equivalent catalogue of the brain proteome is lacking. To provide a starting point, we have performed an in-depth proteome analysis of the adult mouse brain, its major regions ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2020-02-08 | MSV000084941 | MassIVE
ProteomicsInflammatory signaling in human Tuberculosis granulomas is spatially organized
Granulomas are the pathological hallmark of tuberculosis (TB). However, their function and mechanisms of formation remain poorly understood. To understand the role of granulomas in TB, we analyzed the proteomes of granulomas from TB patients in an unbiased fashion. Using laser capture microdissecti...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080720 | MassIVE
UnknownEffects of hospital facilities on patient outcomes after cancer surgery: an international, prospective, observational study.
Not available
S-EPMC9210173 | biostudies-literature
UnknownGlobal variation in postoperative mortality and complications after cancer surgery: a multicentre, prospective cohort study in 82 countries.
Not available
S-EPMC7846817 | biostudies-literature
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