Sort   by:  
 Page size 
TranscriptomicsDetained introns are novel, widespread class of posttranscriptionally-spliced introns
Removal of introns by pre-mRNA splicing is a critical and in some cases rate-limiting step in mammalian gene expression. Deep sequencing of mouse embryonic stem cell RNA revealed many specific internal introns that are significantly more abundant than the other introns within poly(A) selected tran...
ORGANISM(S): Mus musculus 
2015-01-15 | E-GEOD-57231 | biostudies-arrayexpress
MetabolomicsSexual dimorphism in the gonad lipidome of blue mussels (Mytilus sp.): New insights from a global lipidomics approach

Blue mussels (Mytilus sp.) are an economically important species for European aquaculture. Their importance as a food source is expected to increase in the coming net-zero society due to their low environmental footprint; however, their production is affected by anthropogenic stressors and climat...

2024-11-08 | MTBLS8492 | MetaboLights
TranscriptomicsIn vivo structure-function analysis of human Dicer reveals directional processing of precursor miRNAs
Dicer is an RNase III-family endoribonuclease and haploinsufficient tumor suppressor that is required for the biogenesis of miRNAs, yet in vivo structure-function characterization of its RNase IIIA and IIIB domains have not been reported. In murine Dicer knockout fibroblasts, we expressed human Dic...
ORGANISM(S): Mus musculus 
2012-07-13 | E-GEOD-36978 | biostudies-arrayexpress
TranscriptomicstRNAs marked with CCACCA are targeted for degradation
The CCA-adding enzyme adds CCA to the 3' ends of transfer RNAs (tRNAs), a critical step in tRNA biogenesis that generates the amino acid attachment site. We found that the CCA-adding enzyme plays a key role in tRNA quality control by selectively marking unstable tRNAs and tRNA-like small RNAs for de...
ORGANISM(S): Saccharomyces cerevisiae 
2011-11-17 | E-GEOD-33756 | biostudies-arrayexpress
TranscriptomicsProliferation and Tumorigenesis of a Murine Sarcoma Cell Line in the Absence of Dicer
MicroRNAs are a class of short ~22 nucleotide RNAs predicted to regulate nearly half of all protein-coding genes, including many involved in basal cellular processes and organismal development. Although both increases and decreases in the levels of specific miRNAs have been shown to promote tumor d...
ORGANISM(S): Mus musculus 
2012-08-20 | E-GEOD-34825 | biostudies-arrayexpress
TranscriptomicsDicer knockout NSCLC RNAseq and miRseq
Dicer knockout NSCLC mRNAseq profiles the transcriptome, Dicer knockout NSCLC miRseq profiles the miRnome DicerHet and DicerKO NSCLC, 2 biological reps each genotype for mRNAseq, 1 biological rep each for miRseq
ORGANISM(S): Mus musculus 
2014-04-25 | E-GEOD-57043 | biostudies-arrayexpress
TranscriptomicsGenome-wide identification of Ago2 binding sites from mouse embryonic stem cells with and without mature microRNAs
MicroRNAs (miRNAs) are a large family of 19-22nt non-coding RNAs that post-transcriptionally regulate their mRNA targets. Computational algorithms predict that over half of all genes are regulated by miRNAs, yet approaches for experimental identification of miRNA binding sites are now emerging. To ...
ORGANISM(S): Mus musculus 
2011-01-10 | E-GEOD-25310 | biostudies-arrayexpress
TranscriptomicsPromoter directionality is controlled by U1 snRNP and polyadenylation signals
Transcription of the mammalian genome is pervasive, but productive transcription outside of protein-coding genes is limited by unknown mechanisms. In particular, although RNA polymerase II (RNAPII) initiates divergently from most active gene promoters, productive elongation occurs primarily in the s...
ORGANISM(S): Mus musculus 
2013-06-28 | E-GEOD-46433 | biostudies-arrayexpress
TranscriptomicsTranscription factor trapping by RNA in gene regulatory elements (RNA-Seq)
Transcription factors (TFs) bind specific sequences in promoter-proximal and distal DNA elements in order to regulate gene transcription. RNA is transcribed from both promoter-proximal and distal DNA elements, and some DNA-binding TFs have also been shown to bind RNA. These obsevations led us to p...
ORGANISM(S): Mus musculus 
2015-10-29 | E-GEOD-73859 | biostudies-arrayexpress
TranscriptomicsTranscription factor trapping by RNA in gene regulatory elements (GRO-Seq)
Transcription factors (TFs) bind specific sequences in promoter-proximal and distal DNA elements in order to regulate gene transcription. RNA is transcribed from both promoter-proximal and distal DNA elements, and some DNA-binding TFs have also been shown to bind RNA. These obsevations led us to p...
ORGANISM(S): Mus musculus 
2015-10-29 | E-GEOD-68197 | biostudies-arrayexpress
Sort   by:  
 Page size