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MetabolomicsChemotherapy Modulation by a Cancer-Associated Microbiota Metabolite (Targeted metabolomics - 2methylisocitrate)

Understanding how the microbiota produces regulatory metabolites is of significance for cancer and cancer therapy. Using a host-microbe-drug-nutrient 4-way screening approach, we evaluated the role of nutrition at the molecular level in the context of 5-fluorouracil toxicity. Notably, our screens...

2025-09-16 | MTBLS9994 | MetaboLights
UnknownFacilitators and barriers to the implementation of the Primary Care Asthma Paediatric Pathway: a qualitative analysis.
Not available
S-EPMC9109122 | biostudies-literature
TranscriptomicsTranscription profiling of cerebellum from transgenic mice with nuclear and extranuclear polyQ to investigate the role of polyQ in Huntingtons disease
To dissect the impact of nuclear and extranuclear mutant htt on the initiation and progression of disease, we generated a series of transgenic mouse lines in which nuclear localization (NLS) or nuclear export sequences (NES) have been placed N-terminal to the htt exon 1 protein carrying 144 glutamin...
ORGANISM(S): Mus musculus 
2007-07-03 | E-GEOD-3248 | biostudies-arrayexpress
TranscriptomicsMYC threshold required to maintain tumor phenotype
We demonstrate that there is a level of MYC expression that is required for maintaining a tumor phenotype and at this threshold there is a switch from a state of cellular proliferation to a state of proliferative arrest and apoptosis. We analyzed changes in gene expression by oligonucleotide microa...
ORGANISM(S): Mus musculus 
2010-05-25 | E-GEOD-10200 | biostudies-arrayexpress
TranscriptomicsSclerotinia infected vs Mock infected controls in B. napus (Westar)
The fungal pathogen Sclerotinia sclerotiorum infects a broad range of dicotyledonous plant species and is the causative agent of stem rot in Brassica napus. To elucidate the mechanisms underlying the defense response, we studied the patterns of gene expression in a partially resistant variety of Zh...
ORGANISM(S): Brassica napus 
2009-01-31 | E-GEOD-13254 | biostudies-arrayexpress
TranscriptomicsZhong You 821 Sclerotinia infected vs Mock infected controls in B. napus (Zhong You 821)
The fungal pathogen Sclerotinia sclerotiorum infects a broad range of dicotyledonous plant species and is the causative agent of stem rot in Brassica napus. To elucidate the mechanisms underlying the defense response, we studied the patterns of gene expression in a partially resistant variety of Zho...
ORGANISM(S): Brassica napus 
2010-05-06 | E-GEOD-13256 | biostudies-arrayexpress
TranscriptomicsSclerotinia infected vs Mock infected controls in B. napus Westar and Zhong You 821
This SuperSeries is composed of the following subset Series: GSE13254: Sclerotinia infected vs Mock infected controls in B. napus (Westar) GSE13256: Zhong You 821 Sclerotinia infected vs Mock infected controls in B. napus (Zhong You 821) The fungal pathogen Sclerotinia sclerotiorum infects a broad ...
ORGANISM(S): Brassica napus 
2009-01-31 | E-GEOD-13262 | biostudies-arrayexpress
ProteomicsThe human cholesterogenic enzymes DHCR14 and LBR are differentially regulated transcriptionally and post-translationally
Cholesterol synthesis is a tightly regulated process, both transcriptionally and post-translationally. Transcriptional control of cholesterol synthesis is relatively well understood. However, of the ~20 enzymes in cholesterol biosynthesis, post-translational regulation has only been examined for a s...
ORGANISM(S): Homo sapiens (Human) Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 
2020-01-15 | PXD016417 | Pride
Dhcr14 Lbr Cholesterol synthesis enzymes 
ProteomicsHuman adenocarcinoma cell line for phosphoproteomics
Bispecific anti-EGFR/EPHA2 antibody displays strong tumor-suppressing activity
ORGANISM(S): Homo sapiens (Human) 
2023-01-30 | PXD023087 | Pride
Human Cancer Phosphoproteomics Lcmsms 
TranscriptomicsExpression profiling of wheat heads from spring wheat Chinese Spring (CS) and CS-7EL (CS with additional chromosome arm 7EL from Thinopyrum elongatum), after inoculation with either water (mock inoculation) or Fusarium graminearum
The ditelocentric addition line CS-7EL of the spring wheat (Triticum aestivum) cultivar Chinese Spring (CS) contains the long arm of the chromosome 7E from Thinopyrum elongatum (CS-7EL), which confers high resistance to fusarium head blight. It is of great interest to breeders to integrate the resis...
ORGANISM(S): Triticum aestivum 
2015-09-14 | E-GEOD-70797 | biostudies-arrayexpress
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