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ProteomicsThe human cholesterogenic enzymes DHCR14 and LBR are differentially regulated transcriptionally and post-translationally
Cholesterol synthesis is a tightly regulated process, both transcriptionally and post-translationally. Transcriptional control of cholesterol synthesis is relatively well understood. However, of the ~20 enzymes in cholesterol biosynthesis, post-translational regulation has only been examined for a s...
ORGANISM(S): Homo sapiens (Human) Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 
2020-01-15 | PXD016417 | Pride
Dhcr14 Lbr Cholesterol synthesis enzymes 
GenomicsTranscriptome of LBR-null mouse kidneys
Transcriptome of LBR-null mouse kidneys
PRJNA715765 | ENA
ProteomicsCharacterization of a novel Lbr Mutation
We have characterised the product of a novel N terminal deletion of Lbr gene.
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2021-09-10 | PXD024111 | Pride
Lamin b receptor 
GenomicsGenomic positioning in LBR and Lamin A K562 knockout cells
Genomic positioning in LBR and Lamin A K562 knockout cells
PRJNA1095447 | ENA
TranscriptomicsTranscriptome of LBR-null mouse kidneys
We tested overall gene expression change upon chromatin architecture disruption. RNA-seq was performed using nuclear architecture-disrupted mice carrying a loss-of-function mutation in LBR (Lbric-J/ic-J; LBR-null mice). LBR is an INM protein that tethers heterochromatin to the nuclear envelope whose...
ORGANISM(S): Mus musculus 
2021-06-01 | GSE169240 | GEO
UnknownDynamics and Structure-Function Relationships of the Lamin B Receptor (LBR).
Not available
S-EPMC5261809 | biostudies-literature
UnknownA common pathomechanism in GMAP-210- and LBR-related diseases.
Not available
S-EPMC6328090 | biostudies-literature
TranscriptomicsGenomic positioning in LBR and Lamin A K562 knockout cells
To probe the functional consequences of nuclear lamina genome association, we made LMNA, LBR, and double LMNA/LBR K562 knockout lines. We first examined the genome interaction changes with nulcear lamina using LMNB1 DamID seq and further assessed the functional consequences of these changes using RN...
ORGANISM(S): Homo sapiens 
2024-04-04 | GSE263012 | GEO
UnknownDosage effect of zero to three functional LBR-genes in vivo and in vitro.
Not available
S-EPMC3030694 | biostudies-literature
GenomicsSuppression of LBR by miR-340 disrupts chromatin, promotes cell senescence, and enhances senolysis (ATAC-Seq)
Suppression of LBR by miR-340 disrupts chromatin, promotes cell senescence, and enhances senolysis (ATAC-Seq)
PRJNA694653 | ENA
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