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TranscriptomicsCerebellar gene expression data from Mecp2-null and MECP2-transgenic mice
We compared gene expression changes in the cerebellum of mice lacking MeCP2 (Mecp2-null) and mice overexpressing MeCP2 (MECP2-transgenic). A group of postnatal neurodevelopmental disorders collectively referred to as MeCP2 disorders are caused by aberrations in the gene encoding methyl-CpG-binding ...
ORGANISM(S): Mus musculus 
2010-04-10 | E-GEOD-15574 | biostudies-arrayexpress
TranscriptomicsDexamethasone treatment of gut cells
Reference pool RNA versus RNA from dexamethasone treated gut cells.
ORGANISM(S): Mus musculus 
2010-06-05 | E-GEOD-1826 | biostudies-arrayexpress
TranscriptomicsOncogenic MYC induces a dependency on the spliceosome in human cancer
c-MYC (MYC) overexpression or hyperactivation is one of the most common drivers of human cancer. Despite intensive study, the MYC oncogene remains recalcitrant to therapeutic inhibition. Like other classic oncogenes, hyperactivation of MYC leads to collateral stresses onto cancer cells, suggesting t...
ORGANISM(S): Homo sapiens 
2015-09-03 | E-GEOD-66182 | biostudies-arrayexpress
UnknownImmunogenicity, safety, and reactogenicity of heterologous COVID-19 primary vaccination incorporating mRNA, viral-vector, and protein-adjuvant vaccines in the UK (Com-COV2): a single-blind, randomised, phase 2, non-inferiority trial.
Not available
S-EPMC8648333 | biostudies-literature
TranscriptomicsRacial Difference in Human Platelet PAR4 Reactivity Reflects Expression of PCTP and miR-376c
Racial differences in the pathophysiology of atherothrombosis are poorly understood. We explored the function and transcriptome of platelets in healthy black (n=70) and white (n=84) subjects. Numerous differentially expressed (DE) RNAs were associated with both race and PAR4 reactivity, including p...
ORGANISM(S): Homo sapiens 
2013-11-15 | E-GEOD-49921 | biostudies-arrayexpress
UnknownPersistence of immune response in heterologous COVID vaccination schedules in the Com-COV2 study - A single-blind, randomised trial incorporating mRNA, viral-vector and protein-adjuvant vaccines.
Not available
S-EPMC10076082 | biostudies-literature
UnknownSafety and immunogenicity of heterologous versus homologous prime-boost schedules with an adenoviral vectored and mRNA COVID-19 vaccine (Com-COV): a single-blind, randomised, non-inferiority trial.
Not available
S-EPMC8346248 | biostudies-literature
TranscriptomicsA sumoylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis
Myc is an oncogenic transcription factor frequently dysregulated in human cancer. To identify pathways supporting the Myc oncogenic program, we employed a genome-wide RNAi screen for Myc-synthetic-lethal (MySL) genes and uncovered a role for the SUMO-activating-enzyme (SAE1/2). Loss of SAE1/2 enzyma...
ORGANISM(S): Homo sapiens 
2011-12-08 | E-GEOD-34055 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse HSC at various time points after treatment with 5-Fluorouracil
HSC (Sca+ SP) were isolated from 8-12 week C57B6 mice at various time points after treatment with 5-Fluorouracil. RNA was isolated from 50,000-100,000 FACS sorted cells and subjected to two rounds of T7 based linear amplification using Ambion's Message Amp kit. Two replicates from each time point w...
ORGANISM(S): Mus musculus 
2007-11-15 | E-GEOD-1559 | biostudies-arrayexpress
TranscriptomicsHomologous recombination between nonhomologous chromosomes – Recurrent chromosomal translocations mediated by interchromosomal NAHR
Four unrelated families with the same unbalanced translocation der(4)t(4;11)(p16.2;p15.4) were identified. Both of the breakpoint regions in 4p16.2 and 11p15.4 were narrowed to large ~359-kb and ~215-kb low-copy repeat (LCR) clusters, respectively, by aCGH and SNP array analyses. DNA sequencing ena...
ORGANISM(S): Homo sapiens 
2010-08-17 | E-GEOD-23587 | biostudies-arrayexpress
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