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TranscriptomicsLysosomal and phagocytic activity is increased in astrocytes during the progression of amyotrophic lateral sclerosis
The aim of the present study is to combine LCM and microarray analysis to study how astrocytes in the spinal cord of transgenic SOD1 G93A mice and their non-transgenic (NTg) littermates respond to stimuli determined by the presence of the human mutant protein throughout the evolution of the disease ...
ORGANISM(S): Mus musculus 
2015-11-02 | E-GEOD-69166 | biostudies-arrayexpress
UnknownIndividual differences in dopamine uptake in the dorsomedial striatum prior to cocaine exposure predict motivation for cocaine in male rats.
Not available
S-EPMC8357974 | biostudies-literature
TranscriptomicsWhole genome transcriptome analysis identifies indices of fast and slow disease progression in two ALS mouse models
Microarray analysis has been applied to the study of ALS in order to investigate gene expression in whole spinal cord homogenates of SOD1 G93A mice and human ALS cases, although the massive presence of glial cells and inflammatory factors has made it difficult to define which gene expression changes...
ORGANISM(S): Mus musculus 
2013-10-01 | E-GEOD-46298 | biostudies-arrayexpress
TranscriptomicsLoss of nuclear TDP-43 in ALS causes altered expression of splicing machinery and widespread dysregulation of RNA splicing in motor neurons [NSC34]
Aims: Loss of nuclear TDP-43 characterises sporadic and most familial forms of amyotrophic lateral sclerosis (ALS). TDP-43 (encoded by TARDBP) has multiple roles in RNA processing. We aimed to determine whether 1) RNA splicing dysregulation is present in lower motor neurons in ALS and in a motor neu...
ORGANISM(S): Mus musculus 
2014-06-01 | E-GEOD-56503 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of resistant and vulnerable motor neuron subtypes in amyotrophic lateral sclerosis
A consistent clinical feature of amyotrophic lateral sclerosis (ALS) is the sparing of eye movements. Pathological studies have confirmed that there is relative sparing of the cranial motor nuclei of the oculomotor, trochlear and abducens nerves, although pathological changes resembling those seen i...
ORGANISM(S): Homo sapiens 
2013-03-01 | E-GEOD-40438 | biostudies-arrayexpress
MetabolomicsDirect on-swab metabolic profiling of vaginal microbiome:host interactions during pregnancy and preterm birth

The pregnancy vaginal microbiome contributes to risk of preterm birth, the primary cause of death in children under 5 years of age. Here we describe direct on-swab metabolic profiling by Desorption Electrospray Ionization Mass Spectrometry (DESI-MS) for sample preparation-free characterisation of...

2021-09-23 | MTBLS717 | MetaboLights
TranscriptomicsC9ORF72 GGGGCC expanded repeats produce splicing dysregulation which correlates with disease severity in amyotrophic lateral sclerosis [HuEx-1_0-st]
Objective: An intronic GGGGCC-repeat expansion of C9ORF72 is the most common genetic variant of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. The mechanism of neurodegeneration is unknown, but a direct effect on RNA processing mediated by RNA foci transcribed from the repeat seque...
ORGANISM(S): Homo sapiens 
2015-05-08 | E-GEOD-68607 | biostudies-arrayexpress
TranscriptomicsC9ORF72 GGGGCC expanded repeats produce splicing dysregulation which correlates with disease severity in amyotrophic lateral sclerosis [HG-U133_Plus_2]
Objective: An intronic GGGGCC-repeat expansion of C9ORF72 is the most common genetic variant of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. The mechanism of neurodegeneration is unknown, but a direct effect on RNA processing mediated by RNA foci transcribed from the repeat seque...
ORGANISM(S): Homo sapiens 
2015-05-08 | E-GEOD-68605 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis identifies the gene signature of surviving motor neurons in human SOD1-related motor neuron disease
Gene expression profiling has been performed previously on motor cortex and spinal cord homogenates and of sporadic ALS cases and controls, to identify genes and pathways differentially expressed in ALS. More recent studies have combined the use of laser capture microdissection (LCM) with gene expre...
ORGANISM(S): Homo sapiens 
2011-01-01 | E-GEOD-20589 | biostudies-arrayexpress
TranscriptomicsLoss of nuclear TDP-43 in ALS causes altered expression of splicing machinery and widespread dysregulation of RNA splicing in motor neurons [LCM]
Aims: Loss of nuclear TDP-43 characterises sporadic and most familial forms of amyotrophic lateral sclerosis (ALS). TDP-43 (encoded by TARDBP) has multiple roles in RNA processing. We aimed to determine whether 1) RNA splicing dysregulation is present in lower motor neurons in ALS and in a motor neu...
ORGANISM(S): Homo sapiens 
2014-06-01 | E-GEOD-56500 | biostudies-arrayexpress
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