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MetabolomicsIntegrated Proteomics and Metabolomics Analysis Reveals Differential Lipid Metabolism in HUVEC under high and low shear stress
OBJECTIVE: Atherosclerotic plaque development is closely associated with the hemodynamic forces applied to endothelial cells (EC). Among these, shear stress (SS) plays a key role in disease development since changes in flow intensity and direction could stimulate an atheroprone or athero...
2019-07-25 | MTBLS739 | MetaboLights
MetabolomicsImpact of shear stress and moderate electric field on the global metabolic profile of a blended fruit and vegetable juice
This study investigated the impact of moderate electric field (MEF) and shear stress (SS) on the chemical profile of a blended fruit and vegetable juice using untargeted metabolomics. Samples underwent mild thermal treatment, MEF, and a combination of MEF and SS, with subsequent chemical changes ana...
2025-09-30 | MTBLS11719 | MetaboLights
MetabolomicsMetabolomics uncovers the dual effects of high-pressure and ultra-shear processing in juice
This study investigated the chemical changes in a blended fruit and vegetable juice induced by innovative food processing technologies - high-pressure processing (HPP; 400 MPa, 40oC) and ultra-shear technology (UST; 400 MPa, 40 and 72 °C) - in comparison to conventional thermal treatments at 40 and ...
2025-06-25 | MTBLS12637 | MetaboLights
no omics definedTranscription profiling of human mesenchymal stem cells exposed to different profiles of fluid flow-induced shear stress to investigate the effects on the MARK signaling pathway
Effect of different profiles of fluid flow-induced shear stress application on MAPK pathway gene expression in human mesenchymal stem cells
ORGANISM(S): Homo sapiens 
2009-11-24 | E-MEXP-1923 | biostudies-arrayexpress
TranscriptomicsRNA seq of fluid shear stress treated mouse renal epithelial cells
Renal epithelial cells are exposed to mechanical forces due to flow-induced shear stress within the nephrons. We applied RNA sequencing to get a comprehensive overview of fluid-shear regulated genes and pathways in the immortalized renal proximal tubular epithelial cell line. Cells were exposed to l...
ORGANISM(S): Mus musculus 
2018-03-15 | E-MTAB-6640 | biostudies-arrayexpress
TranscriptomicsRNA seq of fluid shear stress treated mouse Pkd1-/- renal epithelial cells
Pkd1-/- renal epithelial cells are exposed to mechanical forces due to flow-induced shear stress within the nephrons. We applied RNA sequencing to get a comprehensive overview of fluid-shear regulated genes and pathways in the immortalized Pkd1-/- renal proximal tubular epithelial cell line. Cells w...
ORGANISM(S): Mus musculus 
2019-03-01 | E-MTAB-6641 | biostudies-arrayexpress
TranscriptomicsShear flow vs. static culture of d9 and d12 megakaryocytes
d9 and d12 Mks were either cultured statically or subjected to shear flow for 30 min; at d9, half the Mks were placed back in culture for 30 min (60 min time point) Megakaryocytes (Mks) are exposed to shear flow as they migrate from the bone marrow hematopoietic compartment into circulation thus rel...
ORGANISM(S): Homo sapiens 
2016-02-01 | E-GEOD-75766 | biostudies-arrayexpress
ProteomicsProfiling of Proteome and Ubiquitome Changesin in endothelial cells in response to shear stress
Shear stress generated by flowing blood has major effects on vascular function. Bends and branches of arteries are exposed to complex blood flow patterns, a mechanical environment that promotes cardiovascular dysfunction and atherosclerosis. The exact mechanisms, by which endothelial cells translate...
ORGANISM(S): Homo sapiens (Human) 
2025-05-23 | PXD024309 | Pride
Endothelial cells Ubiquitome Shear stress Proteome 
TranscriptomicsTranscription profiling by array of human young and senescent HUVECs under static and laminar shear stress conditions
Laminar shear stress due to constant blood flow is known to play a critical role in maintaining vascular health. In contrast, endothelial cell senescence appears to be closely associated with the incidence of vascular disorder. In an attempt to identify functional biomarkers for age-related vascular...
ORGANISM(S): Homo sapiens 
2009-06-01 | E-GEOD-13712 | biostudies-arrayexpress
ModelsKoo2013 - Shear stress induced eNOS expression - Model 3
Andrew Koo, David Nordsletten, Renato Umeton, Beracah Yankama, Shiva Ayyadurai, Guillermo García-Cardeña & C. Forbes Dewey. In silico modeling of shear-stress-induced nitric oxide production in endothelial cells through systems biology. Biophysical Journal 104, 10 (2013). Nitric oxide (NO) produced...
2024-09-02 | BIOMD0000000466 | BioModels
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