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MetabolomicsRegulation impact of Duolang sheep-sourced Ligilactobacillus salivarius on rumen microbiome homeostasis and host metabolism in Hu sheep

Background: Hu sheep, renowned for their prolificacy and economic value, have been introduced to Xinjiang for intensive farming operations. However, their suboptimal adaptation to local harsh environments limits growth efficiency and health management. In contrast, Duolang sheep, an indigenous Xi...

2025-08-02 | MTBLS12659 | MetaboLights
MetabolomicsMulti-omics reveals effects of several rumen bacteria on reproductive performance of sheep

Background: Mounting evidence indicates that the rumen microbiota plays a crucial role in the reproductive health of sheep. However, the potential beneficial effects of rumen microbiota on lambing performance in sheep across different stages of the reproductive cycle and the precise mechanisms un...

2026-03-03 | MTBLS13963 | MetaboLights
MetabolomicsRevealing the Adaptive Metabolic Differences of Different Sheep Breeds in Plateau Areas Based on the Gut-Heart Axis

Gut microbiota plays a significant role in maintaining the homeostasis of the gut internal environment, and the volatile fatty acids (VFAs) produced by it are the main source of energy utilization for the host. The heart, as a key metabolic organ of the body, its energy metabolism efficiency dire...

2025-09-11 | MTBLS12982 | MetaboLights
MetabolomicsTranscript variants of long-chain acyl-CoA synthase 1 have distinct roles in sheep lipid metabolism
Mutton has recently been identified to be a consumer favorite, and intermuscular fat is the key factor in determining meat tenderness. Long-chain acyl-CoA synthetase 1 (ACSL1) is a vital subtype of the ACSL family that is involved in the synthesis of lipids from acyl-CoA and the oxidation of fatty a...
2023-02-06 | MTBLS5808 | MetaboLights
MetabolomicsGenomic and lipidomic actions of nandrolone on detached rotator cuff muscle in sheep
Reversal of fatty infiltration of pennate rotator cuff muscle after tendon release is hitherto impossible. The administration of nandrolone starting at the time of tendon release prevents the increase in fat content, but does not revert established fatty infiltration. We hypothesised that tendon rel...
2017-07-14 | MTBLS322 | MetaboLights
MetabolomicsFermented cotton stalks preserve colonic epithelial integrity in Hu sheep by modulating the microbiota–metabolite–NF-kB/MLCK axis

This study compared three cotton-stalk processing strategies—grinding (FS), steam explosion (PH), and microbial fermentation (FJ)—and evaluated whether the barrier-preserving phenotype observed with fermented cotton stalks is associated with coordinated changes in the microbiota–metabolite milieu...

2026-03-18 | MTBLS14078 | MetaboLights
MetabolomicsEffects of Different Nutritional Levels of Diets on Serum Metabolomics Profiles in Postpartum Tan Sheep
This study investigated the metabolomic characteristics of rumen fluid in postpartum New Zealand ewes after they were fed diets that met 100%, 115% or 130% of their nutritional requirements. Six ewes in each group collected individual blood samples at the time of their first estrus.
2026-07-25 | MTBLS15146 | MetaboLights
MetabolomicsTranscriptomics and metabolomics analysis reveal the anti-oxidation and immune boosting effects of mulberry leaves in growing mutton sheep

INTRODUCTION: Currently, the anti-oxidation of active ingredients in mulberry leaves (MLs) and their forage utilization is receiving increasing attention. Here, we propose that MLs supplementation improves oxidative resistance and immunity.

METHODS: We con...

2023-02-23 | MTBLS6516 | MetaboLights
MetabolomicsSaline pasture improve meat quality in Qinghai Tibetan sheep through changes in the rumen microbiota

Introduction: This study aimed to investigate the effects of natural forage from different regions (saline-alkali and non-saline-alkali areas) on the rumen microbiota, muscle metabolites, and meat quality of Tibetan sheep. 

Methods: Targeted and non-targeted metabolomics were used to c...

2025-07-19 | MTBLS12748 | MetaboLights
MetabolomicsRumen Fluid Metabolomics Analysis of Sheep Under Different Grazing Intensities with Supplementary Feeding

This dataset comprises untargeted LC-MS metabolomics profiles of rumen samples from 8 sheep under moderate grazing with supplementary feeding and 8 sheep under intensive grazing with supplementary feeding. Samples were analyzed using Thermo Fisher Scientific mass spectrometers in positive/negativ...

2025-07-20 | MTBLS12752 | MetaboLights
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