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Intact living conduit vessels (umbilical veins) were exposed to normal or high intraluminal pressure, or low or high shear stress in combination with a physiological level of the other force. We used a unique vascular ex vivo perfusion system. After six hours of perfusion endothelial cells were isol...
ORGANISM(S): Homo sapiens 
Coronary artery disease remains a leading cause of mortality globally. Atherosclerosis develops at arterial sites exposed to disturbed, low, or oscillatory shear stress (OSS), while acute coronary syndromes-triggered by plaque rupture or erosion predominantly occurs in regions subjected to elevated ...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD075178 | Pride
Previously we showed that taste receptor cells in situ in taste buds synthesize insulin. Here we describe a model of pig taste organoid culture in which we have promoted insulin expression by induction of quiescence. The cellular heterogeneity of the lingual epithelium is maintained in the organoids...
ORGANISM(S): Sus scrofa 
2024-01-31 | GSE252240 | GEO
All organisms experience stress and must rapidly respond to changing conditions. Thus, cells have evolved sophisticated rapid-response mechanisms such as post-translational protein modification to rapidly and reversibly modulate protein activity. One such post-translational modification is reversibl...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2025-05-03 | PXD063569 | Pride
Arterial occlusive diseases are major causes of morbidity and mortality. Blood flow to the affected tissue must be restored quickly if viability and function are to be preserved. Collaterals are artery-to-artery or arteriole-to-arteriole interconnections that can bypass an occlusion by providing an ...
ORGANISM(S): Mus musculus 
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