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TranscriptomicsAffymetrix Human Exon 1.0 ST array assay of 15 human MLL-associated samples and 9 human normal bone marrow [HuEx-1_0-st]
To identify potential target genes of leukemia-related miRNAs such as miR-196b and miR-150 in human MLL-associated leukemia, we performed Affymetrix Human Exon 1.0 ST array assay of 15 human MLL-associated samples and 9 human normal bone marrow (including 3 each of CD34+, CD33+, and MNC) cell sample...
ORGANISM(S): Homo sapiens 
2012-08-09 | E-GEOD-34184 | biostudies-arrayexpress
ProteomicsThe NFIB/CARM1 Partnership is a Therapeutic Target for Small Cell Lung Cancer
This project identified NFI family members as CARM1 substrates. NFIB was previously reported to play a critical role in the development of small cell lung cancer. We provided evidence that the arginine methylation of NFIB is required for its oncogenic function in small cell lung cancer.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-11-19 | MSV000090746 | MassIVE
TranscriptomicsAffymetrix gene arrays of leukemic BM samples from 24 mice including 9 primary
To identify such targets of leukemia-related miRNAs such as miR-196b, we conducted Affymetrix gene arrays of leukemic BM samples from 24 mice including 9 primary (including 3 each of negative control, MLL-AF9, and miR-196b+MLL-AF9) and 15 secondary (including 3 negative control, 6 MLL-AF9, and 6 miR...
ORGANISM(S): Mus musculus 
2012-08-09 | E-GEOD-34185 | biostudies-arrayexpress
ProteomicsTo explore potential proteins that bind to usp16
HEK293T cells were transfected with FLag-USP16, and cells were performed with co-immunoprecipitation by Flag antibody or IgG with protein A/G beads.
ORGANISM(S): Homo Sapiens 
2023-09-01 | PXD045021 |
TranscriptomicsIdentification of prognostic gene signatures in AML
Increased expression levels of miR-181 family members have been shown to be associated with favorable outcome in patients with cytogenetically normal acute myeloid leukemia. Here we show that increased expression of miR-181a and miR-181b is also significantly (P < .05; Cox regression) associated wit...
ORGANISM(S): Homo sapiens 
2012-04-03 | E-GEOD-30285 | biostudies-arrayexpress
TranscriptomicsIdentification of miR-181 target genes and a common prognostic gene signature in AML
Increased expression levels of miR-181 family members have been shown to be associated with favorable outcome in patients with cytogenetically normal acute myeloid leukemia. Here we show that increased expression of miR-181a and miR-181b is also significantly (P < .05; Cox regression) associated wit...
ORGANISM(S): Homo sapiens 
2012-04-03 | E-GEOD-30258 | biostudies-arrayexpress
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