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GenomicsATRX tolerates activity-dependent histone H3 M-bM-^@M-^\methyl/phos switchingM-bM-^@M-^] to maintain repetitive element silencing in neurons
ATRX is a member of the SWI2/SNF2 family of chromatin remodeling proteins and primarily functions at heterochromatic loci via its recognition of M-bM-^@M-^XrepressiveM-bM-^@M-^Y histone modifications (e.g., H3K9me3). Despite significant roles for ATRX during normal neural development, as well as its...
ORGANISM(S): Mus musculus 
2015-01-02 | E-GEOD-64062 | biostudies-arrayexpress
ProteomicsExosome-transmitted HSPA9 facilitates bortezomib signaling in multiple myeloma
LC-MS was conducted to screen potential proteins that interacting with HSPA9 in multiple myeloma
ORGANISM(S): Homo Sapiens 
2025-03-13 | PXD061782 |
GenomicsProgram specificity for Ptf1a in PancreasM-BM- versusM-BM- Neural Tube DevelopmentM-BM- correlates with distinctM-BM- collaborating cofactors and chromatin accessibility
Ptf1a is a lineage-specific basic-helix-loop-helix transcription factor critical in the development of both the pancreas and nervous system. How one transcription factor controls diverse programs of gene expression is a fundamental question in developmental biology. To uncover molecular strategies f...
ORGANISM(S): Mus musculus 
2013-08-15 | E-GEOD-47459 | biostudies-arrayexpress
ProteomicsGenomic regions flanking E-box sites influence DNA binding specificity of bHLH transcription factors through DNA shape (different concentrations)
DNA sequence is a major determinant of the binding specificity of transcription factors (TFs) for their genomic targets. However, eukaryotic cells often express, at the same time, TFs with highly similar DNA binding motifs but distinct in vivo targets. Currently, it is not well understood how TFs wi...
ORGANISM(S): Saccharomyces cerevisiae 
2013-03-29 | E-GEOD-44436 | biostudies-arrayexpress
TranscriptomicsGenome-Wide binding sites of two MADS-domain transcription factors SOC1 and SVP in Arabidopsis during the floral transition
The floral transition in Arabidopsis is tightly controlled by complex genetic regulatory networks in response to endogenous and environmental flowering signals. SUPPRESSOR OF OVEREXPRESSION OF CONSTANS 1 (SOC1) and SHORT VEGETATIVE PHASE (SVP), two key MADS-domain transcription factors, perceive the...
ORGANISM(S): Arabidopsis thaliana 
2012-02-01 | E-GEOD-33297 | biostudies-arrayexpress
TranscriptomicsAnalysis of two plant-microbe interactions in N. benthamiana
Nicotiana benthamiana plants were grown to the 8th true leaf development stage with 16 h light at 150 mol s-1 m-2 with 25/17oC day/night temperatures. Colletotrichum orbiculare strain ATCC20767 and Pseudomonas syringae pv. tabaci strain BPIC4 was grown in pure cultures to obtain syringae pv. tabaci ...
ORGANISM(S): Solanum tuberosum Nicotiana benthamiana 
2007-09-01 | GSE8211 | GEO
MetabolomicsMetabolomics Analysis Reveals Tissue-Specific Metabolite Compositions in Leaf Blade and Traps of Carnivorous Nepenthes Plants
Nepenthes is a genus of carnivorous plants that evolved a pitfall trap, the pitcher, to catch and digest insect prey to obtain additional nutrients. Each pitcher is part of the whole leaf, together with a leaf blade. These two completely different parts of the same organ were studied separately in a...
2020-07-10 | MTBLS1783 | MetaboLights
ProteomicsQuantitative Proteomics Reveals Antibiotics Resistance Function of Outer Membrane Proteins in Aeromonas hydrophila
Each colony of A. hydrophila and the OXY-R strain were incubated in 5 mL LB medium overnight, and then diluted in 100 mL fresh LB medium at a ratio of 1:100 and subsequently cultured until the optical density at 600 nm (OD600) reached 1.0. The cultures were harvested via centrifuging for 20 min at 1...
ORGANISM(S): Aeromonas hydrophila subsp. hydrophila ATCC 7966 
2018-11-23 | PXD009622 | Pride
Aeromonas hydrophila， outer membrane proteins， antibiotics resistance Lc-ms/ms 
UnknownCD138- multiple myeloma cells express high level of CHK1 which correlated to overall survival in MM patient.
Not available
S-EPMC7746343 | biostudies-literature
ProteomicsA novel dual histone mark reader ZCWPW2 regulates meiotic recombination through lactylation and transcriptional control in humans and mice
Meiotic recombination ensures proper chromosome segregation and genetic diversity during gametogenesis, and its disruption leads to infertility. It is known that the dual histone methylation writer–reader system, in which PRDM9 deposits H3K4me3 and H3K36me3 marks at nucleosomes to specify recombinat...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2026-01-07 | PXD068838 | Pride
Meiotic recombination  zcwpw1–zcwpw2 complex  prdm9/zcwpw1/zcwpw2 system  ldha  ep300  lactylation 
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