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Metabolic Profiling of Synovial Fluid in Human Temporomandibular Joint Osteoarthritis

INTRODUCTION: Temporomandibular joint (TMJ) osteoarthritis (OA) is a common TMJ degenerative disease with an unclear mechanism. Synovial fluid (SF), an important component of TMJ, contains various proteins and metabolites that may directly contribute to OA. The present study aime...

2025-05-27 | MTBLS9665 | MetaboLights

Metabolic Profiling of Synovial Fluid in Human Temporomandibular Joint Osteoarthritis

2025-05-27 | MTBLS9662 | MetaboLights

Recreating the natural evolutionary trend in key microdomains provides an effective strategy for engineering of a thermomicrobial N-demethylase.

Not available

S-EPMC8892156 | biostudies-literature

miR-198 inhibits the progression of renal cell carcinoma by targeting BIRC5.

Not available

S-EPMC8296723 | biostudies-literature

DeepFLR Facilitates False Localization Rate Control in Phosphoproteomics

Site-specific phosphorylation events affect nearly all the cellular processes and correct phosphosite localization plays an important role in biological or medical health studies. However, direct false localization rate (FLR) control remains challenging in phosphoproteomics. Here, we propose DeepFLR...

ORGANISM(S): Homo Sapiens

2023-04-04 | PXD037580 |

IL-33 stabilizes the transcription factor IRF1

Interleukin-33 (IL-33) functions both as a secreted cytokine and as a nuclear factor, with pleiotropic roles in tumor growth and immunity. Here, we explored its role in hepatocellular carcinoma (HCC) and identified that its nuclear function mediated a mechanism of immune escape.