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MetabolomicsArginine starvation kills tumor cells through aspartate exhaustion and mitochondrial dysfunction
Defective arginine synthesis, due to the silencing of argininosuccinate synthase 1 (ASS1), is a common metabolic vulnerability in cancer, known as arginine auxotrophy. Understanding how arginine depletion kills arginine-auxotrophic cancer cells will facilitate the development of anti-cancer therapeu...
2019-11-07 | MTBLS745 | MetaboLights
ProteomicsZinc-dependent Zip7-MAZ-MYBL2 axis promotes prostate cancer metastasis
Screening reveals that a zinc transporter Zip7 was upregulated in metastatic PCa and related to poor progression. Zip7 silencing inhibits PCa cell migration and invasion in vitro and bone-metastasis in vivo. Mechanistically, we identify that Zip7 mainly interacts with MAZ in cytoplasm to facilita...
ORGANISM(S): Homo Sapiens 
2026-01-14 | PXD073047 |
ProteomicsIdentification of p72-interacting proteins in porcine alveolar macrophages
To explore the potential mechanisms regulating p72 stability, we performed co-immunoprecipitation using an anti-p72 antibody in ASFV-infected PAMs, followed by mass spectrometry analysis to identify host factors interacting with p72.
ORGANISM(S): Sus Scrofa Domesticus 
2026-01-18 | PXD073232 |
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