Sort   by:  
 Page size 
TranscriptomicsDefined hypoxic model timecourse of H37Rv and H37Rv:deltadosR
Background: A significant body of evidence accumulated over the last century suggests a link between hypoxic microenvironments within the infected host and the latent phase of tuberculosis. Studies to test this correlation have identified the M. tuberculosis initial hypoxic response, controlled by ...
ORGANISM(S): Mycobacterium tuberculosis 
2008-02-20 | E-GEOD-9331 | biostudies-arrayexpress
TranscriptomicsMycobacterium tuberculosis H37Rv transcriptional response to antibacterial agents
Bacteria commonly adapt to stresses by altering gene expression. To understand the response of M. tuberculosis (MTB) to various antibacterial agents, we performed transcriptomics on MTB bacilli exposed to several test compounds as well as known drugs (capreomycin, cycloserine, ethionamide, isoniazi...
ORGANISM(S): Mycobacterium tuberculosis 
2015-11-11 | E-GEOD-71200 | biostudies-arrayexpress
UnknownSulfamate Acetamides as Self-Immolative Electrophiles for Covalent Ligand-Directed Release Chemistry.
Not available
S-EPMC9936582 | biostudies-literature
TranscriptomicsMapping and manipulating the M. tuberculosis transcriptome using a transcription factor overexpression-derived regulatory network
Expression data from transcription factor over expression experiments (Abstract from paper will be appended after publication) TFOE are matched to the ChIP-seq experiment done simultaneously.
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2014-07-04 | E-GEOD-59086 | biostudies-arrayexpress
TranscriptomicsDistinct classes of genes behave as either drivers or dependents of replication timing switches (Replication-Timing).
Duplication of the genome in mammalian cells occurs in a defined temporal order referred as its replication-timing program (RT). RT is regulated in units of 400-800 Kb referred as replication domains (RDs) and changes dynamically during development. Changes in RT are generally coordinated with trans...
ORGANISM(S): Homo sapiens 
2015-05-28 | E-GEOD-63428 | biostudies-arrayexpress
ProteomicsProteomic analysis of extracellular vesicles and conditioned medium from human Adipose-derived Stem/Stromal Cells and Dermal Fibroblasts
Conditioned medium (CM) and extracellular vesicles (EV) from human Adipose-derived Stem/stromal cells (ASC) and Dermal fibroblasts (DF) can represent valid cell substitutes in regenerative medicine and other therapeutic applications. Whether one of the two cell products should be preferred over the ...
ORGANISM(S): Homo sapiens (Human) 
2020-12-23 | PXD020219 | Pride
Adipose-derived stromal cells Label-free quantitative proteomics Extracellular vesicles Dermal fibroblasts Conditioned medium Secretome 
TranscriptomicsFolate Pathway Disruption Leads to Critical Depletion of Methionine Derivatives in Mycobacterium tuberculosis
In this study, screening efforts identified novel antifolates with potent, targeted activity against whole cell Mycobacterium tuberculosis. Liquid chromatography-mass spectrometry analysis of antifolate-treated cultures revealed unique metabolic disruption, including decreased pools of methionine a...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2014-03-19 | E-GEOD-55979 | biostudies-arrayexpress
ProteomicsThe Mycobacterium tuberculosis O-phosphorylation landscape
LC-MS/MS tryptic peptide data comprising both label free (phosphoproteome) and TMT10 (global and phosphoproteome) analysis of mycobacterium tuberculosis mutants (WT, GoF, and LoF) grown at stationary phase. Data was searched with MS-GF+ (TMT) and MaxQuant (label free).
ORGANISM(S): Mycobacterium Tuberculosis (ncbitaxon:1773) 
2021-10-21 | MSV000088254 | MassIVE
TranscriptomicsTowards understanding the biological function of the unusual chaperonin GroEL1 of Mycobacterium tuberculosis
Expression data from wild type (H37Rv) and GroEL1(H37RvΔgroEL1::Hyg) mutant strains under a range of environmental stresses The 60 kDa heat shock proteins, also known as GroELs are components of the essential protein folding machinery of the cell, but are also dominant antigens in many infectious di...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2015-05-14 | E-GEOD-68856 | biostudies-arrayexpress
ProteomicsTIPRL1 and its ATM-dependent phosphorylation modulate the DNA Damage Response to promote radiotherapy resistance in head and neck cancer
TIPRL1 (target of rapamycin signaling pathway regulator-like 1) is a known interactor and inhibitor of protein phosphatases PP2A, PP4 and PP6 – all pleiotropic modulators of the DNA Damage Response (DDR). Here, we describe a new role for TIPRL1 in the radiotherapy (RT) response of Head and Neck Squa...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD044931 | Pride
Ataxia telangiectasia mutated (atm) kinase/ dna damage response (ddr)/ head and neck squamous cell carcinoma (hnscc)/ radioresistance/ target of rapamycin signaling pathway regulator-like 1 (tiprl1) 
Sort   by:  
 Page size