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TranscriptomicsKDM5C safeguards the appropriate timing of early neurodevelopment
We generated human induced pluripotent cells from intellectual disability patients carrying the c.2T>C mutation in KDM5C (Called “Mutant”). We generated a paired, isogenic human iPS cell line (called “Corrected”) using CRISPR/Cas9 and PiggyBac gene-editing technologies and conducted neuronal differe...
ORGANISM(S): Homo sapiens 
2023-10-13 | E-MTAB-7551 | biostudies-arrayexpress
TranscriptomicsRNA-Seq in neurons from E16.5 mouse embryonic cortices from WT and SMCX KO mice
We conducted RNA-Seq (using Direct Ligation of Adapters to first strand cDNA) in neurons from E16.5 mouse embryonic cortices from WT and SMCX KO mice and harvested after 10 days in vitro culture. We sequenced RNA samples after 10 days in vitro cultures in biological and technical duplicates. 4 RNA s...
ORGANISM(S): Mus musculus 
2016-01-27 | E-GEOD-61024 | biostudies-arrayexpress
GenomicsChIP-Seq of H3K4 methylation in neurons isolated from E16.5 mouse embryonic cortices from WT and SMCX KO mice
We conducted ChIP-Seq of H3K4 methylation in neurons isolated from E16.5 mouse embryonic cortices from WT and SMCX KO mice and harvested after 10 days in vitro culture. We sequenced H3K4me1, H3K4me3 ChIP and Input samples from mouse embryonic cortical neurons cultured in vitro for 10 days. Experimen...
ORGANISM(S): Mus musculus 
2016-01-27 | E-GEOD-61023 | biostudies-arrayexpress
UnknownCrowd-sourced machine learning prediction of long COVID using data from the National COVID Cohort Collaborative.
Not available
S-EPMC11462169 | biostudies-literature
GenomicsChIPseq examination of EAP-1 binding across generations of spr-5(by101) mutant worms
How epigenetic information is transmitted from generation to generation remains largely unknown. Deletion of the C. elegans Histone H3 lysine 4 dimethyl (H3K4me2) demethylase spr-5 leads to inherited accumulation of the euchromatic H3K4me2 mark and progressive decline in fertility. Here we identifie...
ORGANISM(S): Caenorhabditis elegans 
2014-04-08 | E-GEOD-52102 | biostudies-arrayexpress
MetabolomicsMyeloid PFKFB3-mediated glycolysis promotes kidney fibrosis
Excessive renal fibrosis is a common pathology in progressive chronic kidney diseases. Inflammatory injury and aberrant repair processes contribute to the development of kidney fibrosis. Myeloid cells, particularly monocytes/macrophages, play a crucial role in kidney fibrosis by releasing their proi...
2024-03-12 | MTBLS8278 | MetaboLights
Proteomicssdspage
exp 4: SDSPAGE
ORGANISM(S): Saccharomyces Cerevisiae 
2005-12-31 | PAe000158 | PeptideAtlas
ProteomicsAn aspartyl pseudoprotease dominates the secretory hydrolase landscape of the skin commensal Malassezia in situ
Malassezia globosa is abundant and prevalent on sebaceous areas of the human skin. Genome annotation reveals that M. globosa possesses a repertoire of secreted hydrolytic enzymes relevant for lipid and protein metabolism on the skin. In-gel proteomics identifies a predicted aspartyl protease, MGL_33...
ORGANISM(S): Cellular Organisms 
2023-11-23 | PXD042508 | JPOST Repository
TranscriptomicsSynthetic Lethality (SLAM) Project Data
Synthetic lethality is a type of genetic interaction in which two non-lethal mutations acting together result in a loss of viability. Such interactions are important for the insights they may offer into how gene functions are organized into distinct cellular processes. The datasets in this Series re...
ORGANISM(S): Saccharomyces cerevisiae 
2013-02-28 | E-GEOD-14217 | biostudies-arrayexpress
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