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TranscriptomicsOrphan nuclear receptor TR4 uses non-equivalent binding sites to regulate gene targets from proximal and distal transcriptional regulatory elements during human definitive erythropoiesis
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2015-02-04 | E-GEOD-54761 | biostudies-arrayexpress
TranscriptomicsExpression data of differentiated human erythroid cells with or without Tranylcypromine (TC) treatment
We found that LSD1 inhibition by a monoamine oxidase inhibitor, tranylcypromine (TC), could enhance fetal gamma globin expression. Global effects of TC on erythroid expession were conducted by HG-U219 array strips. Primary human erythroid cells, which differentiated from CD34+ cells for 8 days, wer...
ORGANISM(S): Homo sapiens 
2013-02-16 | E-GEOD-42078 | biostudies-arrayexpress
TranscriptomicsDevelopmental transcriptome analysis of human erythropoiesis
We profiled the dynamic, comprehensive transcriptome during human erythroid differentiation in vitro. The erythroid cells at day 4, 8, 11 and 14 differentiation stages were harvested and sequenced by Illumia 72 bp paired-end sequencing format, respectively. Expression profiling of erythroid cells on...
ORGANISM(S): Homo sapiens 
2014-05-05 | E-GEOD-54602 | biostudies-arrayexpress
TranscriptomicsOrphan nuclear receptor TR4 uses non-equivalent binding sites to regulate gene targets from proximal and distal transcriptional regulatory elements during human definitive erythropoiesis [RNA-seq]
We knocked down TR4 expression by 2 lentiviral mediated vectors at day 11 of erythroid differentiation in order to identify TR4 downstream targets. Two lentiviruses and one empty control were used to knockdown TR4 expression. The cells were harvested at day 11 during erythroid differentiation.
ORGANISM(S): Homo sapiens 
2015-02-04 | E-GEOD-54760 | biostudies-arrayexpress
GenomicsOrphan nuclear receptor TR4 uses non-equivalent binding sites to regulate gene targets from proximal and distal transcriptional regulatory elements during human definitive erythropoiesis [ChIP-seq]
In this study, we resolved the genome-wide binding of TR4 in differentiating human erythroid cells by performing chromatin immunoprecipitation followed by next-generation sequencing (ChIP-seq). We found that TR4 preferentially binds to DR1 elements in the promoters of its target genes, and that the ...
ORGANISM(S): Homo sapiens 
2015-02-04 | E-GEOD-54759 | biostudies-arrayexpress
ProteomicsCDK5RAP3, a UFL1 substrate adaptor, is critical for liver development
Protein modification by ubiquitin and ubiquitin-like proteins (UBLs) regulates numerous biological functions. The UFM1 system, a novel UBL conjugation system, is implicated in mouse development and hematopoiesis. However, its broad biological functions and working mechanisms remain largely elusive. ...
ORGANISM(S): Mus Musculus 
2019-01-14 | PXD012340 |
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