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ProteomicsExosome-transmitted HSPA9 facilitates bortezomib signaling in multiple myeloma
LC-MS was conducted to screen potential proteins that interacting with HSPA9 in multiple myeloma
ORGANISM(S): Homo Sapiens 
2025-03-13 | PXD061782 |
ProteomicsHMGB2 promote ESCC tumorigenesis and predict neoadjuvant therapy response
Recent studies have demonstrated that chronic stress can enhance the development of multiple human diseases, including cancer. However, the role of chronic stress in esophageal carcinogenesis and its underlying molecular mechanisms remain unclear. This study uncovered that dysregulated cholesterol m...
ORGANISM(S): Mus Musculus 
2025-01-09 | PXD059616 |
ProteomicsChronic stress-induced cholesterol metabolism abnormalities promote ESCC tumorigenesis and predict neoadjuvant therapy response
chronic stress activates the GCR-HMGB2-LDLR axis via cortisol release, leading to abnormal cholesterol metabolism and ultimately promoting esophageal carcinogenesis
ORGANISM(S): Homo Sapiens 
2025-01-09 | PXD059578 |
ProteomicsTargeting high circDNA2v levels in colorectal cancer induces cellular senescence and elicits an anti-tumor secretome
The efficacy of immunotherapy against colorectal cancer (CRC) is impaired by insufficient immune cell recruitment into the tumor microenvironment. Our study shows that targeting circDNA2v, a circular RNA commonly overexpressed in CRC, can be exploited to elicit cytotoxic T-cell recruitment. CircDNA2...
ORGANISM(S): Homo Sapiens 
2024-04-11 | PXD051359 |
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