Inducing mitochondrial uncoupling (mUncoupling) is an attractive therapeutic strategy for treating metabolic diseases because it leads to calorie-wasting by reducing the efficiency of oxidative phosphorylation (OXPHOS) in mitochondria. Here we report a safe mUncoupler, OPC-163493, which has unique p...
Freshly resected colorectal cancer tissues and adjacent normal tissues of 17 individuals were incubated in serum-free medium.
Extracellular vesicles were isolated from the medium with ultracentrifugation method.
