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MetabolomicsAntidiabetic and cardiovascular beneficial effects of a liver-localized mitochondrial uncoupler
Inducing mitochondrial uncoupling (mUncoupling) is an attractive therapeutic strategy for treating metabolic diseases because it leads to calorie-wasting by reducing the efficiency of oxidative phosphorylation (OXPHOS) in mitochondria. Here we report a safe mUncoupler, OPC-163493, which has unique p...
2019-05-24 | MTBLS836 | MetaboLights
UnknownCD271 on melanoma cell is an IFN-?-inducible immunosuppressive factor that mediates downregulation of melanoma antigens
Not available
ORGANISM(S): Homo sapiens 
S-ECPF-GEOD-51259 | biostudies-other
TranscriptomicsCD271 on melanoma cell is an IFN-M-NM-3-inducible immunosuppressive factor that mediates downregulation of melanoma antigens
In this study, we have identified candidates for IFN-M-NM-3-inducible CTLs-suppressive factors in melanoma cells using cDNA microarray analysis Double-stranded cDNAs were synthesized from mRNAs extracted from melanoma cell lines that express melanoma-associated antigen recognized by T cells 1 (MART-...
ORGANISM(S): Homo sapiens 
2014-04-01 | E-GEOD-51259 | biostudies-arrayexpress
TranscriptomicsMYBPH, a novel transcriptional target of NKX2-1/TTF-1, inhibits ROCK1 and actomyosin assembly, and reduces cell motility and tumor metastasis
Cell migration driven by actomyosin filament assembly is a critical step in tumour invasion and metastasis. Herein, we report identification of myosin binding protein H (MYBPH) as a transcriptional target of NKX2-1 (also known as TTF-1 and TITF1), a lineage-survival oncogene in lung adenocarcinoma. ...
ORGANISM(S): Homo sapiens 
2011-12-22 | E-GEOD-26721 | biostudies-arrayexpress
TranscriptomicsIntegrated array-CGH and expression microarray analyses on medulloblastomas in heterozygous Ptch1 mice
This SuperSeries is composed of the following subset Series: GSE19360: Integrated array-CGH and expression microarray analyses on medulloblastomas in heterozygous Ptch1 mice, expression GSE19381: Integrated array-CGH and expression microarray analyses on medulloblastomas in heterozygous Ptch1 mice,...
ORGANISM(S): Mus musculus 
2010-07-14 | E-GEOD-19384 | biostudies-arrayexpress
TranscriptomicsIdentification of mir-342-3p functionally associated with transcriptional activity of MYC in lung cancer
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2016-01-06 | E-GEOD-66760 | biostudies-arrayexpress
TranscriptomicsIdentification of mir-342-3p functionally associated with transcriptional activity of MYC in lung cancer [cell culture]
Accumulating evidence indicates that altered miRNA expression is crucially involved in lung cancer development, but only little has been elucidated about how MYC, an archetypical oncogene, is regulated by miRNAs, especially through a mechanism involving the MYC cofactor(s). In this study, we aimed a...
ORGANISM(S): Homo sapiens 
2016-01-06 | E-GEOD-66758 | biostudies-arrayexpress
TranscriptomicsIntegrated array-CGH and expression microarray analyses on medulloblastomas in heterozygous Ptch1 mice, expression
Genomic radiation signature illuminates low-dose effects with sharply reflected transcriptome in Ptch1-deficient medulloblastomas. Cancer risks of low-dose radiation are of great concern especially in relation to rapidly increasing medical exposures; however, their accurate assessments cope with man...
ORGANISM(S): Mus musculus 
2010-07-14 | E-GEOD-19360 | biostudies-arrayexpress
TranscriptomicsMicroarray-based global mapping of integration sites of retrotransposon, intracisternal A-particle, in mouse genome
Mammalian genomes have evolutionary harbored numerous mobile elements, a part of which are still active and evoke genomic instability. Their movement and positional diversity occasionally result in phenotypic changes and variation by causing altered expression and disruption of neighboring genes in...
ORGANISM(S): Mus musculus 
2008-05-03 | E-GEOD-9572 | biostudies-arrayexpress
TranscriptomicsIntegrated array-CGH and expression microarray analyses on medulloblastomas in heterozygous Ptch1 mice, aCGH 2
Genomic radiation signature illuminates low-dose effects with sharply reflected transcriptome in Ptch1-deficient medulloblastomas. Cancer risks of low-dose radiation are of great concern especially in relation to rapidly increasing medical exposures; however, their accurate assessments cope with man...
ORGANISM(S): Mus musculus 
2010-07-14 | E-GEOD-19382 | biostudies-arrayexpress
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