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TranscriptomicsThe transcription factor CDX2 maintains active enhancer in intestinal villus cells in vivo (expression data)
We established whether partner transcription factor binding, chromatin structure, or gene expression is compromised upon loss of partner factors cdx2 or hnf4a in mouse intestinal villi This metadata file describes the gene expression componant of that data Intestinal epithelia were collected from mo...
ORGANISM(S): Mus musculus 
2013-02-05 | E-GEOD-34567 | biostudies-arrayexpress
GenomicsHistone methylation and transcription factor binding during intestinal cell differentation
Cell differentiation requires epigenetic modulation of tissue-specific genes and activities of master transcriptional regulators, which are recognized for their dominant control over cellular programs. Using novel epigenomic methods, we characterized enhancer elements specifically modified in differ...
ORGANISM(S): Mus musculus 
2010-11-17 | E-GEOD-23436 | biostudies-arrayexpress
TranscriptomicsCdx2 transcription factor binding in intestinal villus and gene expression profiling in Cdx mutant mice
We conditionally inactivated mouse Cdx2, a dominant regulator of intestinal development, and mapped its genome occupancy in adult intestinal villi. Although homeotic transformation, observed in Cdx2-null embryos, was absent in mutant adults, gene expression and cell morphology were vitally compromis...
ORGANISM(S): Mus musculus 
2011-04-13 | E-GEOD-24633 | biostudies-arrayexpress
GenomicsThe transcription factor CDX2 maintains active enhancer in intestinal villus cells in vivo (ChIP-seq data)
We established whether partner transcription factor binding, chromatin structure, or gene expression is compromised upon loss of partner factors cdx2 or hnf4a in mouse intestinal villi. This metadata file describes the ChIP-seq componant of that data Intestinal epithelia were collected from mouse je...
ORGANISM(S): Mus musculus 
2013-02-05 | E-GEOD-34566 | biostudies-arrayexpress
TranscriptomicsEstrogen receptor prevents p53-dependent apoptosis in breast cancer
More than two thirds of breast cancers express the estrogen receptor (ER) and depend on estrogen for growth and survival. Therapies targeting ER function including aromatase inhibitors that block the production of estrogens and ER antagonists that alter ER transcriptional activity play a central rol...
ORGANISM(S): Homo sapiens 
2012-11-02 | E-GEOD-39870 | biostudies-arrayexpress
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