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TranscriptomicsA methyltransferase EHMT1 controls brown adipose cell fate and adaptive thermogenesis through a PRDM16 complex
Brown adipose tissue (BAT) dissipates chemical energy in the form of heat, as a defense against hypothermia and obesity. Current evidence indicates that brown adipocytes arise from Myf5+-dermotomal precursors through the action of a PRDM16-C/EBP-_ transcriptional complex; however, the underlying mec...
ORGANISM(S): Mus musculus 
2013-11-07 | E-MTAB-1704 | biostudies-arrayexpress
ProteomicsMouse adipocyte phosphoproteome during differentiation
Kosaku Shinoda, Kana Ohyama, Yutaka Hasegawa, Hsin-Yi Chang, David W. Scheel, Louis Z. Sharp, Haemin Hong, Takashi Hosono, Mayu Ogura, Ayaka Sato, Yasushi Ishihama, and Shingo Kajimura. Phosphoproteomics Identifies CK2 As a Negative Regulator of Beige Adipocyte Thermogenesis and Energy Expenditure. ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2015-08-28 | MSV000079278 | MassIVE
TranscriptomicsMolecular characterization of supraclavicular and subcutaneous abdominal adipose tissue samples collected during CE (cold exposure) and TN (thermoneutral) conditions
Recent studies suggest that brown adipose tissue (BAT) plays a role in energy and glucose metabolism in humans. However, the physiological significance of human BAT in lipid metabolism remains unknown. To gain insight regarding the mechanisms of accelerated lipid metabolism in relation to the cold-a...
ORGANISM(S): Homo sapiens 
2016-05-26 | E-MTAB-4031 | biostudies-arrayexpress
TranscriptomicsRNA-seq comparison of primary mouse classical brown, beige, and white adipocytes
Classical brown adipocytes in interscapular BAT (Myf-5 derived) and inducible beige cells in WAT (non-Myf-5 derived) have distinct developmental origins, although both cell types have morphological and biochemical characteristics of brown fat such as the expression of UCP1. This raises an important ...
ORGANISM(S): Mus musculus 
2015-03-16 | E-MTAB-2624 | biostudies-arrayexpress
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