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TranscriptomicsExpression data from the mouse ES cell-derived differentiated cells treated with or without MPA
Mycophenolic acid (MPA), effectively promoted ES cell pancreatic differentiation with a concomitant reduction of neuronal cells. The targets of MPA were investigated by microarray analysis of cells treated on day 5 with MPA and harvested on day 6 and 8. Cells were harvested for RNA extraction and hy...
ORGANISM(S): Mus musculus 
2016-03-02 | E-GEOD-78797 | biostudies-arrayexpress
TranscriptomicsExpression data from undifferentiated human ES cell line, khES3 grown using complete, leucine or lysine deprived media
In undifferentiated human ES cells, 48hr Leucine deprivation (delta Leu) or Lysine deprivation (delta Lys) led to apoptosis. We used microarrays to detail the mollecular mechanism of cell-death caused by Leu, Lys deprivation in undifferentiated ES cells. Cells were harvested at undifferentiated stag...
ORGANISM(S): Homo sapiens 
2014-04-17 | E-GEOD-55284 | biostudies-arrayexpress
TranscriptomicsExpression data from the transplanted mouse islets into hyperglycemic and normoglycemic mice at 6 hours post-transplantation
insulin treatment protects islets from the initial rapid loss that is usually observed after transplantation and positively affects the outcome of islet transplantation in Akita mice. To study the molecular mechanism underlying the improved islet survival, expression profile analyses was performed t...
ORGANISM(S): Mus musculus 
2014-04-18 | E-GEOD-55764 | biostudies-arrayexpress
TranscriptomicsExpression data from undifferentiated human ES cell line, khES3, grown using complete or methionine deprived media and ES cell derived endoderm
In undifferentiated human ES cells, 5hr Met deprivation (delta Met) led to decreased proliferation, and prolonged 24hr Met deprivation resulted in G0-G1 phase cell cycle arrest, which then led to apoptosis. We used microarrays to detail the molecular mechanism of cell-death caused by Met deprivation...
ORGANISM(S): Homo sapiens 
2014-04-17 | E-GEOD-55283 | biostudies-arrayexpress
TranscriptomicsExpression data from undifferentiated human ES cell line, khES3, grown using complete, methionine, leucine or lysine deprived media and ES cell derived endoderm
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2014-04-17 | E-GEOD-55285 | biostudies-arrayexpress
TranscriptomicsDNA methylation profiling of embryonic stem cell differentiation into the three germ layers [MeDIP analysis]
Embryogenesis is tightly regulated by multiple levels of epigenetic systems such as DNA methylation, histone modification, and chromatin remodeling. DNA methylation patterns are erased in primordial germ cells and in the interval immediately following fertilization. Subsequent reprogramming occurs...
ORGANISM(S): Mus musculus 
2012-02-15 | E-GEOD-32080 | biostudies-arrayexpress
TranscriptomicsDNA methylation profiling of embryonic stem cell differentiation into the three germ layers [Expression analysis]
Embryogenesis is tightly regulated by multiple levels of epigenetic systems such as DNA methylation, histone modification, and chromatin remodeling. DNA methylation patterns are erased in primordial germ cells and in the interval immediately following fertilization. Subsequent reprogramming occurs...
ORGANISM(S): Mus musculus 
2012-02-15 | E-GEOD-32081 | biostudies-arrayexpress
TranscriptomicsDNA methylation profiling of embryonic stem cell differentiation into the three germ layers
This SuperSeries is composed of the following subset Series: GSE32080: DNA methylation profiling of embryonic stem cell differentiation into the three germ layers [MeDIP analysis] GSE32081: DNA methylation profiling of embryonic stem cell differentiation into the three germ layers [Expression analys...
ORGANISM(S): Mus musculus 
2012-02-15 | E-GEOD-32082 | biostudies-arrayexpress
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