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TranscriptomicspiRNAs initiate an epigenetic memory of non-self RNA in the C. elegans germline.
Organisms exhibit a fascinating array of gene-silencing pathways, which have evolved in part, to confront invasive nucleic acids such as transposons and viruses. A key question raised by the existence of these pathways is how do they distinguish M-bM-^@M-^\selfM-bM-^@M-^] from M-bM-^@M-^\non-selfM-b...
ORGANISM(S): Caenorhabditis elegans 
2012-07-17 | E-GEOD-38724 | biostudies-arrayexpress
TranscriptomicsThe Vasa homolog RDE-12 engages target mRNA and a secondary-Argonaute WAGO-1 to promote RNAi in C. elegans
Argonaute proteins (AGOs) are key nuclease effectors of RNA interference (RNAi) [1]. Although purified AGOs can mediate a single round of target-RNA cleavage in vitro, accessory factors are required for siRNA loading and to achieve multiple-target turnover [2, 3]. To identify AGO co-factors we immun...
ORGANISM(S): Caenorhabditis elegans 
2014-06-24 | E-GEOD-54396 | biostudies-arrayexpress
TranscriptomicsCSR-1 mediates RNA activation, RNAa, a self-RNA recognition pathway that promotes gene expression in the C. elegans germline
Epigenetic inheritance is the transmission of information independently of the nucleotide sequence of the genome. A fundamental question in biology is to what extent does epigenetics contribute to trans-generational inheritance. Here we investigate the role of Argonaute-small-RNA pathways in epigen...
ORGANISM(S): Caenorhabditis elegans 
2013-12-23 | E-GEOD-49532 | biostudies-arrayexpress
TranscriptomicsArgonautes promote male fertility and provide a paternal memory of germline gene expression in C. elegans
During each life cycle germ cells preserve and pass on both genetic and epigenetic information. In C. elegans, the ALG-3/4 Argonaute (AGO) proteins and their small-RNA cofactors are expressed during male gametogenesis and promote male fertility. Here we show that the CSR-1 AGO functions with ALG-3/4...
ORGANISM(S): Caenorhabditis elegans 
2013-12-19 | E-GEOD-49672 | biostudies-arrayexpress
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