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ProteomicsA novel class of CLK kinases inhibitors that target SRSF10 and promote p53mediated cytotoxicity on human colorectal cancer cells
The elevated expression of the splicing regulator SRSF10 in metastatic colorectal cancer (CRC) stimulates the production of the pro-tumorigenic Bclaf1-L splice variant. We discovered a group of small molecules with an aminothiazole carboxamide core (GPS167, GPS192 and others) that decrease productio...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD022333 | Pride
Clk kinases inhibitor Srsf10 Human colorectal cancer cells 
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