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TranscriptomicsTranscriptome analysis of alternative splicing events regulated by SRSF10 reveals position-dependent splicing modulation.
Splicing factor SRSF10 is known to function as a sequence-specific splicing activator. Here, we used RNA-seq coupled with bioinformatics analysis to identify the extensive splicing network regulated by SRSF10 in chicken cells. We found that SRSF10 promoted both exon inclusion and exclusion. Function...
ORGANISM(S): Gallus gallus 
2014-01-22 | E-GEOD-53354 | biostudies-arrayexpress
TranscriptomicsSRSF10 regulates alternative splicing and is required for adipocyte differentiation.
During adipocyte differentiation, significant alternative splicing changes occur in association with the adipogenic process. However, little is known about roles played by splicing factors in this process. We observed that mice deficient for the splicing factor SRSF10 exhibit severely impaired devel...
ORGANISM(S): Mus musculus 
2014-05-12 | E-GEOD-54226 | biostudies-arrayexpress
TranscriptomicsPAR-CLIP analysis of YTHDC1, SRSF1, SRSF3, SRSF7, SRSF9 and SRSF10 in human HeLa cells
Label the cells overexpressed Flag tagged YTHDC1, SRSF1, SRSF3, SRSF7, SRSF9 and SRSF10 with 4-SU, the RNA bound by YTHDC1 and SRSF proteins can be got by Flag IP followed by RNA isolation by using the TRIzol (Invitrogen) reagent by following the company manual.the RNA was then used for library prep...
ORGANISM(S): Homo sapiens 
2016-02-17 | E-GEOD-71096 | biostudies-arrayexpress
TranscriptomicsTranscriptomics analysis of gene expression in normal and YTHDC1, SRSF1, SRSF3, SRSF7, SRSF9 or SRSF10 deficient human HeLa cells
RNA was isolated from and YTHDC1, SRSF1, SRSF3, SRSF7, SRSF9 and SRSF10 deficient human HeLa cells using the TRIzol (Invitrogen) reagent by following the company manual. For all samples the RNA integrity was checked using an Agilent Bioanalyzer 2100. All samples showed a RIN (RNA integrity number) o...
ORGANISM(S): Homo sapiens 
2016-02-17 | E-GEOD-71095 | biostudies-arrayexpress
ProteomicsA novel class of CLK kinases inhibitors that target SRSF10 and promote p53mediated cytotoxicity on human colorectal cancer cells
The elevated expression of the splicing regulator SRSF10 in metastatic colorectal cancer (CRC) stimulates the production of the pro-tumorigenic Bclaf1-L splice variant. We discovered a group of small molecules with an aminothiazole carboxamide core (GPS167, GPS192 and others) that decrease productio...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD022333 | Pride
Clk kinases inhibitor Srsf10 Human colorectal cancer cells 
TranscriptomicsNext Generation Sequencing Analysis of Wild Type and SRSF10-/- embryonic day 13.5 heart Transcriptomes
We generated the SRSF10 -/- mice, and collected their embryonic heart at 13.5 and controls. Then, we extracted RNAs of embryonic heart and performed next generation sequencing. By comparing sequcing data from WT and SRSF10 -/- samples, we profiled the alternative splicing events and gene expression ...
ORGANISM(S): Mus musculus 
2015-04-01 | E-GEOD-66965 | biostudies-arrayexpress
GenomicsRNA-seq of THP1 cells with SRSF10 knockdown
RNA-seq of THP1 cells with SRSF10 knockdown
PRJNA1481196 | ENA
GenomicsThe regulation of transcriptome in HCC cells by SRSF10 [Huh7_shSRSF10_RNAseq]
The regulation of transcriptome in HCC cells by SRSF10 [Huh7_shSRSF10_RNAseq]
PRJNA1135244 | ENA
GenomicsSRSF10 is essential for progenitor spermatogonia expansion by regulating alternative splicing
SRSF10 is essential for progenitor spermatogonia expansion by regulating alternative splicing
PRJNA787907 | ENA
GenomicsSRSF10 regulates proliferation of neural progenitor cells and affects neurogenesis in the developing mouse neocortex
SRSF10 regulates proliferation of neural progenitor cells and affects neurogenesis in the developing mouse neocortex
PRJNA936877 | ENA
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