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TranscriptomicsNovartis 12 Strain Diet Sex Survey
High-fat diets are associated with increased obesity and metabolic disease in mice and humans. Here we used analysis of variance (ANOVA) to scrutinize a microarray data set consisting of 10 inbred strains of mice from both sexes fed atherogenic high-fat and control chow diets. An overall F-test was ...
ORGANISM(S): Mus musculus 
2008-12-10 | E-GEOD-10493 | biostudies-arrayexpress
TranscriptomicsGlobal gene expression profiling of spontaneous hepatocellular carcinoma in B6C3F1 mice: Similarities in the molecular landscape to human liver cancer.
Hepatocellular carcinoma (HCC) is an important cause of morbidity and mortality worldwide. Although the risk factors of human HCC are well known, the molecular characterization of this disease is complex, and treatment options in general remain poor. The use of rodent models to study human cancer ha...
ORGANISM(S): Mus musculus 
2011-06-06 | E-GEOD-26538 | biostudies-arrayexpress
TranscriptomicsGlobal Differential Gene Expression Analysis of Spontaneous Lung Tumors in B6C3F1 Mice: Comparison to Human Non-Small Cell Lung Cancer
Introduction: Lung cancer is the leading cause of cancer-related death in people. There are several chemically induced and genetically modified mouse models used to study lung cancer. We hypothesized that spontaneous murine (B6C3F1) lung tumors can serve as a model to study human non-small cell lung...
ORGANISM(S): Mus musculus 
2012-06-21 | E-GEOD-31013 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of whole Drosophila brains fron animals exposed to sleep deprivation
Analysis of brain of Canton-S females deprived of sleep by perturbations during their normal sleep period. Perturbation effect also assessed during their active period to control for its effect during sleep deprivation. Results suggest processes altered during prolonged wakefulness and during sleep.
ORGANISM(S): Drosophila melanogaster 
2007-07-06 | E-GEOD-4174 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse brain during spontaneous sleep and prolonged wakefulness
These studies address temporal changes in gene expression during spontaneous sleep and extended wakefulness in the mouse cerebral cortex, a neuronal target for processes that control sleep; and the hypothalamus, an important site of sleep regulatory processes. We determined these changes by comparin...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-6514 | biostudies-arrayexpress
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