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UnknownTim-3 co-stimulation promotes short-lived effector T cells, restricts memory precursors, and is dispensable for T cell exhaustion.
Not available
S-EPMC5877951 | biostudies-literature
TranscriptomicsExpression data from CD8+TIM-3+ and CD8+TIM-3- T cells sorted from follicular lymphoma lymph nodes
Exhaustion markers are expressed by T lymphocytes in Follicular Lymphoma (FL). Through these, TIM-3 has been recently identified as a poor pronostic factor when expressed by FL CD4+ T cells. Before this study, there was no molecular characterization of unstimulated CD8+ T cells, expressing - or not ...
ORGANISM(S): Homo sapiens 
2016-12-15 | GSE84072 | GEO
UnknownAllograft rejection is restrained by short-lived TIM-3+PD-1+Foxp3+ Tregs.
Not available
S-EPMC3386804 | biostudies-literature
ProteomicsAPEX protemics of the inhibitory receptors CLTA-4, LAG-3 and TIM-3
APEX proteomics data of the vesicular proteome of the T cell inhibitory receptors CTLA-4, LAG3 and TIM3 as described in https://biorxiv.org/cgi/content/short/2023.07.21.550019v1
ORGANISM(S): Mus musculus (Mouse) 
2023-10-26 | PXD044064 | Pride
Mouse T cell Apex Inhibitory receptor 
GenomicsTIM-3, LAG-3, or 2B4 gene disruptions increase the anti-tumor response of engineered T cells
TIM-3, LAG-3, or 2B4 gene disruptions increase the anti-tumor response of engineered T cells
PRJNA1077704 | ENA
UnknownImpaired functional responses in follicular lymphoma CD8+TIM-3+ T lymphocytes following TCR engagement.
Not available
S-EPMC5135226 | biostudies-literature
GenomicsHomo sapiens
Expression data from CD8+TIM-3+ and CD8+TIM-3- T cells sorted from follicular lymphoma lymph nodes
PRJNA327936 | ENA
TranscriptomicsTIM-3, LAG-3, or 2B4 gene disruptions increase the anti-tumor response of engineered T cells
In adoptive T cell therapy, the long term therapeutic benefits in patients treated with engineered tumor specific T cells are limited by the lack of long term persistence of the infused cellular products and by the immunosuppressive mechanisms active in the tumor microenvironment. Exhausted T cells ...
ORGANISM(S): Homo sapiens 
2024-02-27 | GSE256035 | GEO
UnknownTIM-3, LAG-3, or 2B4 gene disruptions increase the anti-tumor response of engineered T cells.
Not available
S-EPMC10953820 | biostudies-literature
UnknownActivation-Induced TIM-4 Expression Identifies Differential Responsiveness of Intestinal CD103+ CD11b+ Dendritic Cells to a Mucosal Adjuvant.
Not available
S-EPMC4933342 | biostudies-literature
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