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GenomicsStreptomyces sp. SHP 1-2
Streptomyces sp. SHP 1-2 Genome sequencing and assembly
PRJNA661228 | ENA
GenomicsLiver ChIP-seq analysis in FGF19-treated mice reveals SHP as a global transcriptional partner of SREBP-2
Background: Fibroblast growth factor-19 (FGF19) is an intestinal hormone that mediates postprandial metabolic responses in the liver. The unusual orphan nuclear receptor, Small Heterodimer Partner (SHP), acts as a co-repressor for many transcriptional factors and has been implicated in diverse biolo...
ORGANISM(S): Mus musculus 
2015-11-12 | E-GEOD-74913 | biostudies-arrayexpress
ProteomicsConcomitant deletion of Shp-1 and Shp-2 in T cells fails to improve anticancer responses 
Anticancer T cells acquire a dysfunctional state characterized by poor effector function and expression of inhibitory receptors, such as programmed cell death protein 1 (PD-1). Blockade of PD-1 signalling leads to T cell reinvigoration and is increasingly applied as an effective anticancer treatment...
ORGANISM(S): Mus musculus (Mouse) 
2022-09-29 | PXD034897 | Pride
Shp-2  shp-1  ptpn11  ptpn6  t cell exhaustion  cancer immunotherapy  inhibitory receptors  pd-1 checkpoint therapy  
GenomicsTargeting PDGFRa-activated Glioblastoma through Specific Inhibition of SHP-2-mediated Signaling
Targeting PDGFRa-activated Glioblastoma through Specific Inhibition of SHP-2-mediated Signaling
PRJNA523607 | ENA
GenomicsMyeloid-specific SHP-2 ablation alters the fate commitment of myeloid cells and induces anti-tumor immunity
Myeloid-specific SHP-2 ablation alters the fate commitment of myeloid cells and induces anti-tumor immunity
PRJNA777536 | ENA
GenomicsLiver ChIP-seq analysis in FGF19-treated mice reveals SHP as a global transcriptional partner of SREBP-2
Background: Fibroblast growth factor-19 (FGF19) is an intestinal hormone that mediates postprandial metabolic responses in the liver. The unusual orphan nuclear receptor, Small Heterodimer Partner (SHP), acts as a co-repressor for many transcriptional factors and has been implicated in diverse biolo...
ORGANISM(S): Mus musculus 
2015-11-12 | GSE74913 | GEO
TranscriptomicsTargeting PDGFRa-activated Glioblastoma through Specific Inhibition of SHP-2-mediated Signaling
SHP-2 is a nonreceptor protein tyrosine phosphatase encoded by the PTPN11 gene and is critical for PDGFR-driven gliomagenesis. SHP099, a novel and potent SHP-2 inhibitor, preferentially attenuated the tumorigenicity of GBM and glioma stem-like cells (GSCs) compared to normal brain cells or neural p...
ORGANISM(S): Mus musculus 
2021-02-20 | GSE126892 | GEO
TranscriptomicsMyeloid-specific SHP-2 ablation alters the fate commitment of myeloid cells and induces anti-tumor immunity
We generated mice with conditional targeting of the Ptpn11 gene (encoding for Shp-2) in T cells (Shp-2fl/flLckCre) or myeloid cells (Shp-2fl/flLysMCre). Although no difference in tumor growth was observed between Shp-2fl/flLckCre and control mice and both groups were similarly benefitted by PD-1 blo...
ORGANISM(S): Mus musculus 
2022-10-26 | GSE187394 | GEO
UnknownSHP-2 and PD-1-SHP-2 signaling regulate myeloid cell differentiation and antitumor responses.
Not available
S-EPMC9810534 | biostudies-literature
UnknownInteraction of SHP-2 SH2 domains with PD-1 ITSM induces PD-1 dimerization and SHP-2 activation.
Not available
S-EPMC7078208 | biostudies-literature
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