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TranscriptomicsModeling tumor subtypes in vivo using lineage restricted transgenic shRNA
Expression analysis from two genetically engineered mouse models of osteosarcoma determine the expression profile of mouse osteosarcoma Human osteosarcoma (OS) is comprised of three different subtypes: fibroblastic, chondroblastic and osteoblastic. We previously generated a mouse model of fibroblast...
ORGANISM(S): Mus musculus 
2013-03-28 | E-GEOD-38742 | biostudies-arrayexpress
MetabolomicsImpact of genetic suppression (shRNA) of ALDH1A1 expression in human colon cancer cell line (COLO320)
Not available
ORGANISM(S): Homo sapiens 
ST001093 | MetabolomicsWorkbench
TranscriptomicsA receptor tyrosine kinase network comprised of FGFRs, EGFR, ERBB2, and MET drives growth and survival of HNSCC cell lines.
We have previously shown that some gefitinib insensitive head and neck squamous cell carcinoma (HNSCC) cell lines exhibit dominant autocrine fibroblast growth factor receptor (FGFR) signaling. Herein, we deployed a whole genome loss-of-function screen to identify genes whose knockdown potentiated th...
ORGANISM(S): Homo sapiens 
2013-05-03 | E-GEOD-39305 | biostudies-arrayexpress
TranscriptomicsLentiviral shRNA library screen to identify growth-related genes in malignant melanoma
Little is known about genes that promote melanoma cell growth and proliferation. siRNAs may be used to address the role of individual genesin these processes. RNAi library screens were used in the past to gain a comprehensive overview of all genes involved in cell growth, proliferation, migration an...
ORGANISM(S): Homo sapiens 
2014-01-24 | E-GEOD-46675 | biostudies-arrayexpress
TranscriptomicsA genome-scale shRNA resource for transgenic RNAi in Drosophila
Existing transgenic RNAi resources in Drosophila utilize the expression of long double stranded hairpin RNAs and are powerful tools for the identification and characterization of genes involved in various processes. However, they are ineffective to knockdown genes during oogenesis, an important mode...
ORGANISM(S): Drosophila melanogaster 
2011-03-26 | E-GEOD-27039 | biostudies-arrayexpress
TranscriptomicsshRNA Screening Identifies JMJD1C as being required for Leukemia Maintenance
We used a mouse model of human AML induced by the MLL-AF9 fusion oncogene, and an epigenetic shRNA library to screen for novel potential drug targets. One of the best candidate drug targets identified in these screens was Jmjd1c. Depletion of Jmjd1c impairs growth and colony formation of mouse MLL-A...
ORGANISM(S): Homo sapiens 
2013-08-22 | E-GEOD-50048 | biostudies-arrayexpress
TranscriptomicsGene expression data following Cyclin T2 and Cyclin T1 depletion by shRNA in HeLa cells
We have characterized gene expression changes in HeLa cells following long term depletion of Cyclin T2 or Cyclin T1 using shRNA HeLa cells were transduced with VSV-G pseudotyped lentiviral vectors expressing shRNA against either Cyclin T2 or Cyclin T1. As a control, cells were transduced with shRNA...
ORGANISM(S): Homo sapiens 
2011-08-02 | E-GEOD-28339 | biostudies-arrayexpress
GenomicsRNA-seq of control shRNA and BHLHE40 shRNA HeLa-S3 cells
RNA-seq of control shRNA and BHLHE40 shRNA HeLa-S3 cells
PRJNA573663 | ENA
GenomicsACC-MESO1 cells: Control shRNA vs USP22 shRNA
ACC-MESO1 cells: Control shRNA vs USP22 shRNA
PRJNA414177 | ENA
GenomicsDNAseq data from human ovarian carcinoma cell lines subjected to shRNA TRC1.0 library
The hallmark of human cancer is heterogeneity, mirroring the complexity of genetic and epigenetic alterations acquired during oncogenesis. We extracted DNA of 14 cultured human ovarian carcinoma cell lines subjected to pooled shRNA screen using TRC 1.0 library, and performed DNAseq. 14 ovarian carc...
ORGANISM(S): Homo sapiens 
2013-05-21 | E-GEOD-45420 | biostudies-arrayexpress
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