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MetabolomicsLoss of SPTSSA Impairs Mitochondrial Function and Neuronal Differentiation in SH-SY5Y Neuroblastoma Cells
Sphingolipids are bioactive membrane and signaling lipids that not only shape cellular architecture but also orchestrate a network of interconnected metabolic pathways. Their core building blocks, sphingoid bases, are synthesized by the serine palmitoyltransferase (SPT) complex. At its core, the SPT...
2026-10-09 | MTBLS15875 | MetaboLights
TranscriptomicsTranscription profiling of human human neuroblastoma SH-SY5Y cells identifies molecular effectors of unconjugated bilirubin
This SuperSeries is composed of the following subset Series:; GSE16656: Transcriptome analysis identifies molecular effectors of unconjugated bilirubin in human neuroblatoma SH-SY5Y cells: 24h; GSE16766: Transcriptome analysis identifies molecular effectors of unconjugated bilirubin in human neurobl...
ORGANISM(S): Homo sapiens 
2009-12-02 | E-GEOD-16768 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human human neuroblastoma SH-SY5Y cells: 1h identifies molecular effectors of unconjugated bilirubin
The deposition of unconjugated bilirubin (UCB) in selected regions of the brain results in irreversible neuronal damage, or Bilirubin Encephalopathy (BE). Although UCB impairs a large number of cellular functions, the basic mechanisms of neurotoxicity have not yet been fully clarified. While cells c...
ORGANISM(S): Homo sapiens 
2009-11-29 | E-GEOD-16766 | biostudies-arrayexpress
ProteomicsQuantitative proteomic analysis of HIV-1 Tat-induced dysregulation in SH-SY5Y neuroblastoma cells
Despite affecting up to 70% of HIV+ patients and being the leading cause of dementia in patients under 40 years, the molecular mechanisms involved in the onset of HAND are not well understood. To address this, we performed SILAC-based quantitative proteomic analysis on HIV-Tat treated SH-SY5Y neurob...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-03-18 | MSV000083590 | MassIVE
TranscriptomicsTranscription profiling of human neuroblastoma SH-SY5Y cells: 4h identifies molecular effectors of unconjugated bilirubin
The deposition of unconjugated bilirubin (UCB) in selected regions of the brain results in irreversible neuronal damage, or Bilirubin Encephalopathy (BE). Although UCB impairs a large number of cellular functions, the basic mechanisms of neurotoxicity have not yet been fully clarified. While cells c...
ORGANISM(S): Homo sapiens 
2009-12-02 | E-GEOD-16767 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human neuroblastoma cell line SH-SY5Y transfected to produce phenotypes with low, medium or high levels of beta-amyloid peptides with 40 or 42 amino acids
Alzheimer's disease (AD) is characterized by massive neurodegeneration and multiple changes in cellular processes, including neurogenesis. Proteolytic processing of the amyloid precursor protein (APP) plays a central role in AD. Due to varying APP processing, several beta-amyloid peptides are genera...
ORGANISM(S): Homo sapiens 
2009-06-01 | E-MEXP-1913 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human neuroblatoma SH-SY5Y cells: 24h identifies molecular effectors of unconjugated bilirubin
The deposition of unconjugated bilirubin (UCB) in selected regions of the brain results in irreversible neuronal damage, or Bilirubin Encephalopathy (BE). Although UCB impairs a large number of cellular functions, the basic mechanisms of neurotoxicity have not yet been fully clarified. While cells c...
ORGANISM(S): Homo sapiens 
2009-11-29 | E-GEOD-16656 | biostudies-arrayexpress
TranscriptomicsProfiling neuroblastoma SH-SY5Y with Paraquat treatment
Human SH-SY5Y neuroblastoma cells treated with paraquat, a neurotoxic herbicide which both catalyzes the formation of reactive oxygen species (ROS) and induces mitochondrial damage in animal models was profiled using Affimetrix Exon 1.0 ST GeneChips® Human SH-SY5Y neuroblastoma cells was compared w...
ORGANISM(S): Homo sapiens 
2010-12-22 | E-GEOD-21305 | biostudies-arrayexpress
TranscriptomicsParkinson's disease-associated DJ-1 is required for the expression of GDNF receptor Ret in human neuroblastoma cells
DJ-1 is an atypical peroxiredoxin-like peroxidase that may act as a redox-dependent chaperone and a regulator of transcription. To explore DJ-1-mediated transcriptional control in Parkinsonâ??s disease (PD), we generated human neuroblastoma cells with inducible knock-down of DJ-1 expression. We then...
ORGANISM(S): Homo sapiens 
2010-04-28 | E-GEOD-17204 | biostudies-arrayexpress
GenomicsInduction of ER stress in SHSY5Y human neuroblastoma cells by thapsigargin treatment
Induction of ER stress in SHSY5Y human neuroblastoma cells by thapsigargin treatment
PRJNA1107564 | ENA
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