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TranscriptomicsIntegration of high-resolution methylome and transcriptome analyses to dissect epigenomic changes in childhood acute lymphoblastic leukemia
B-cell precursor acute lymphoblastic leukemia (pre-B ALL) is the most common pediatric cancer. Although the genetic origin of the disease remains unclear, epigenetic modifications including DNA methylation are suggested to contribute significantly to leukemogenesis. We assessed the DNA methylation s...
ORGANISM(S): Homo sapiens 
2013-06-04 | E-GEOD-38235 | biostudies-arrayexpress
TranscriptomicsInitiation Pausing of 80S Ribosome on mRNA Is Governed by 5’UTR and Responsive to mTORC1 Signaling
This SuperSeries is composed of the following subset Series: GSE25331: Initiation pausing of mRNA translation controlled by mTORC1 signaling (microarray) GSE25626: Initiation pausing of mRNA translation controlled by mTORC1 signaling (RNA-Seq) Refer to individual Series
ORGANISM(S): Mus musculus 
2011-11-12 | E-GEOD-25627 | biostudies-arrayexpress
TranscriptomicsGenome-wide profiling of gene expression under electro-acupuncture treatment on MI heart in rats
Purpose: Acupuncture exerts cardioprotective effects on several types of cardiac injuries, especially myocardial ischemia (MI). In order to elucidate the potential mechanisms, RNA-seq by next generation sequencing was used to identify the rat genome-wide alterations after MI and EA treatment in t...
ORGANISM(S): Rattus norvegicus 
2016-03-21 | E-GEOD-54132 | biostudies-arrayexpress
UnknownRational mpox vaccine design: immunogenicity and protective effect of individual and multicomponent proteins in mice.
Not available
S-EPMC11951338 | biostudies-literature
TranscriptomicsGene Expression Atlas for Human Embryogenesis
Gene expression profiling has provided critical insights into the molecular pathways underlying development of model organisms, however little information is available on regulated gene expression during human embryogenesis. We have now filled this important gap of knowledge by performing genome-wid...
ORGANISM(S): Homo sapiens 
2010-07-06 | E-GEOD-15744 | biostudies-arrayexpress
TranscriptomicsIncreased Persistence of gamma-H2AX as a Novel Approach to High Content Screening for Small Molecule Radiosensitizers
This study is about high content screening small molecule compound as radiosensitizer. Two compounds were got finally from a chemical bank. Our data indicate cancer cell lines became more sensitive to radiation after treatment with both two compounds respectively. In order to know the mechanism, mic...
ORGANISM(S): Homo sapiens 
2012-10-01 | E-MTAB-845 | biostudies-arrayexpress
TranscriptomicsInitiation Pausing of 80S Ribosome on mRNA Is Governed by 5’UTR and Responsive to mTORC1 Signaling (Microarray)
Recent studies have revealed that the mRNA translation is punctuated by ribosomal pauses through the body of transcripts. However, little is known about its physiological significance and regulatory aspects. Here we present a multi-dimensional ribosome profiling approach to quantify the dynamics o...
ORGANISM(S): Mus musculus 
2011-11-12 | E-GEOD-25331 | biostudies-arrayexpress
TranscriptomicsInitiation Pausing of 80S Ribosome on mRNA Is Governed by 5'UTR and Responsive to mTORC1 Signaling (RNA-Seq)
Recent studies have revealed that the mRNA translation is punctuated by ribosomal pauses through the body of transcripts. However, little is known about its physiological significance and regulatory aspects. Here we present a multi-dimensional ribosome profiling approach to quantify the dynamics o...
ORGANISM(S): Mus musculus 
2011-11-12 | E-GEOD-25626 | biostudies-arrayexpress
TranscriptomicsGenome-wide characterization of allelic chromatin in human fibroblast and lymphoblastoid cell lines by high-density allele-specific analyses
Cis-regulatory variants are predicted to mediate the majority of the common genetic risk associated to complex disease, yet the specific causal variants have thus far been poorly characterized. Allele-specific (AS) assessment of chromatin modifications has the potential to elucidate specific cis-reg...
ORGANISM(S): Homo sapiens 
2013-10-18 | E-GEOD-51272 | biostudies-arrayexpress
TranscriptomicsStress-dependent CHIP/Daxx interaction suppresses the p53 apoptotic program
Our previous studies have implicated CHIP as a co-chaperone/ubiquitin ligase, whose activities yield protection against stress-induced apoptotic events. In this report, we demonstrate a stress-dependent interaction between CHIP (carboxyl terminus of Hsp70-interacting protein) and Daxx, death domain-...
ORGANISM(S): Mus musculus 
2010-04-03 | E-GEOD-14339 | biostudies-arrayexpress
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