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TranscriptomicsExpression data from mesothelial (LP9) and mesothelioma cells (HMESO) inhibited for extracellular-regulated kinase (ERK) 1, 2, or 5
Extracellular-regulated kinases (ERK1/2 and 5) are known to play important roles in growth and drug resistance of various cancers. Here we show roles of inhibition of ERK1, ERK2, or ERK5 on gene expression profiles of epithelioid malignant mesothelioma (MM) cells (HMESO). Untransfected human mesothe...
ORGANISM(S): Homo sapiens 
2010-05-08 | E-GEOD-21750 | biostudies-arrayexpress
TranscriptomicsMicroarray data from CREB inhibited and control mesothelioma cells
Cyclic AMP response element binding protein (CREB) is known to play important roles in growth and drug resistance of various cancers. Here we show roles of inhibition of CREB1 on gene expression profile of malignant mesothelioma (MM) cells (Hmeso and H2373/PPMMill). Stably transfected HMESO or H2373...
ORGANISM(S): Homo sapiens 
2013-10-21 | E-GEOD-51447 | biostudies-arrayexpress
TranscriptomicsDifferential susceptibility of human pleural and peritoneal mesothelial cells to asbestos exposure
We hypothesize that the observed differences in incidences of pleural and peritoneal malignant mesothelioma (MM) are the result of differences in the direct response of these cell types to asbestos rather than to differences mediated by the in vivo microenvironment. To test this hypothesis, we chara...
ORGANISM(S): Homo sapiens 
2015-03-02 | E-GEOD-63966 | biostudies-arrayexpress
TranscriptomicsAlterations in Gene Expression in Human Mesothelial Cells Correlate with Mineral Pathogenicity
Human mesothelial cells (LP9/TERT-1) were exposed to low and high (15 and 75 μm2/cm2 dish) equal surface area concentrations of crocidolite asbestos, nonfibrous talc, fine titanium dioxide (TiO2), or glass beads for 8 or 24 h. RNA was then isolated for Affymetrix microarrays, GeneSifter analysis and...
ORGANISM(S): Homo sapiens 
2011-09-18 | E-GEOD-14034 | biostudies-arrayexpress
TranscriptomicsGene expression data of primary human bronchial epithelial cells exposed to crocidolite asbestos and cristobalite silica mineral dusts
Gene expression microarrays were used to compare gene alterations induced by exposure to equitoxic doses of crocidolite asbestos and cristobalite silica in an isolate of normal human bronchial epithelial cells. Primary human bronchial epithelial cells (NHBE) were exposed to crocidolite asbestos, cri...
ORGANISM(S): Homo sapiens 
2014-10-29 | E-GEOD-62769 | biostudies-arrayexpress
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