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ProteomicsGlobal interactomics analysis of the human Duffy antigen receptor for chemokines
The Duffy antigen receptor for chemokines or DARC is a seven trans-membrane glycoprotein that is expressed primarily on the surface of red blood cells. Additionally, it is also expressed on the surface of post-venular endothelial cells, Purkinje cells of the cerebellum, inner ear hair cells, cells o...
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD051602 | Pride
Duffy antigen receptor G protein-coupled receptors Chemokine receptors Cellular signaling Cryogenic-electron microscopy 
ProteomicsIntrinsic bias at non-canonical, β-arrestin-coupled seven transmembrane receptors
G protein-coupled receptors (GPCRs) are typically characterized by their seven transmembrane (7TM) architecture, and interaction with two universal signal-transducers namely, the heterotrimeric G-proteins and β-arrestins (βarrs). Synthetic ligands and receptor mutants have been designed to elicit tr...
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD027887 | Pride
Gpcr kinases Gpcrs Β-arrestins Complement c5a Biased signaling Β-arrestin-coupled receptors Seven transmembrane receptors 
ProteomicsMolecular mechanism of distinct chemokine engagement and functional divergence of the human Duffy antigen receptor
The Duffy antigen receptor, also known as FY glycoprotein or CD234, is a seven transmembrane (7TM) protein expressed primarily at the surface of red blood cells, and it displays strikingly promiscuous binding to multiple pro- and anti-inflammatory chemokines. Here, we comprehensively profile transdu...
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD044876 | Pride
Duffy antigen receptor G protein-coupled receptors Chemokine receptors Cellular signaling Cryogenic-electron microscopy Phosphoproteomics 
UnknownPolypill with or without Aspirin in Persons without Cardiovascular Disease.
Not available
S-EPMC7116860 | biostudies-literature
UnknownSARS-CoV-2 seroprevalence among the general population and healthcare workers in India, December 2020-January 2021.
Not available
S-EPMC8132496 | biostudies-literature
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