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TranscriptomicsTranscriptome analysis in macrophages treated with type I interferon, heat-killed Listeria monocytogenes, or both.
To define the group of genes which is synergistically induced by cooperative activity of the type I interferon - activated Jak/STAT pathway and other pathways, we treated bone marrow-derived macrophages (BMDM) with heat-killed Listeria (hkL; non-STAT pathways activated), type I interferon alone (onl...
ORGANISM(S): Mus musculus 
2015-06-15 | E-MTAB-3015 | biostudies-arrayexpress
GenomicsChIPseq profile of RNA polymerase (pol II), the p65 subunit of NFkB, STAT1 and STAT2 in bone marrow derived macrophages after treatment with IFNb, heat-killed Listeria monocytogenes (hkL), or both.
Using ChIP-Seq analysis we define genes induced in macrophages through synergistic transcriptional activation by NFkB and the IFNb-activated transcription factor ISGF3.
ORGANISM(S): Mus musculus 
2015-06-15 | E-MTAB-2972 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of Ras induced Epithelial to Mesenchymal Transition (EMT) in Madin-Darby Canine Kidney (MDCK) cells
To gain more information about EMT induced by oncogenic Ras in MDCK cells, we performed RNA-seq of MDCK and MDCK-Ras cells and compared their genome-wide gene expression profiles.
ORGANISM(S): Canis lupus familiaris 
2016-02-03 | E-MTAB-3301 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis in macrophages isolated from wild-type, Stat1Y701F or Stat1-/- mice infected with Listeria monocytogenes for 6, 12, or 24 hours
We infected the bone marrow-derived macrophages (BMDM) isolated from WT, Stat1Y701F or Stat1-/- mice were infected with Listeria monocytogenes for 6, 12 or 24h, or left untreated in order to find out how the transcriptome of these genotypes differs during infection.
ORGANISM(S): Mus musculus 
2016-01-26 | E-MTAB-3598 | biostudies-arrayexpress
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