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ProteomicsAlzheimer Disease (AD) and AD model detergent insoluble proteomes
Characterizing the detergent insoluble brain proteome of sporadic late-onset Alzheimer’s disease (LOAD) has identified proteins and pathways associated with disease pathogenesis. Similar studies in early onset Alzheimer’s disease cases due to presenilin-1 mutations (PS1-EOAD), along with more detail...
ORGANISM(S): Homo sapiens (Human) 
2019-06-25 | PXD005321 | Pride
In-gel digestion Dquan Neurodegeneration In house xic quantitation 
ProteomicsTargeted quantification of detergent-insoluble RNA-binding proteins in Alzheimer’s disease reveals disease-specific coaggregation signatures
Core spliceosome and related RNA-binding proteins aggregate in Alzheimer’s disease (AD) brain even in early asymptomatic stages (AsymAD) of disease. To assess the specificity of RNA-binding protein aggregation in AD, we developed a targeted mass spectrometry approach to quantify broad classes of RNA...
ORGANISM(S): Homo sapiens (Human) 
2021-03-17 | PXD022144 | Pride
Parkinson’s disease Alzheimer’s disease Insoluble proteins Rna-binding proteins Parallel reaction monitoring (prm) mass spectrometry Human brains 
ProteomicsTBK1 interacts with tau and enhances neurodegeneration in tauopathy
One of the defining pathological features of Alzheimer’s Disease (AD) is the deposition of neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau in the brain. Aberrant activation of kinases in AD has been suggested to enhance phosphorylation and toxicity of tau, making the responsible t...
ORGANISM(S): Homo sapiens (Human) 
2022-03-01 | PXD025301 | Pride
Coip Ikk Tbk1 mapt tau phosphorylation 
ProteomicsDeepMRM: targeted proteomics data interpretation package with deep learning-based object detection
LC-MRM-MS/MS data of 66 Pancreatic ductal adenocarcinoma patients. Includes peak list files (.mzML), quantification results (.tsv) and raw files (.d) of the three replicate data of all patients.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-07-19 | MSV000089914 | MassIVE
ProteomicsPeptide centric detection of cross-linked peptides using PASEF, MeroX, and Skyline
Cross-linking mass spectrometry (XL-MS) has evolved into a pivotal technique for probing protein interactions, with recent ad-vancements significantly enhancing its analytical potential. This technical note presents advancements in cross-linking mass spec-trometry (XL-MS) through the implementation ...
ORGANISM(S): Bos Taurus 
2024-05-13 | PXD047307 | panorama
ProteomicsQuantitative XL-MS Analysis of HHARI in the presence or absence of 4EHP
RING-Between-RING (RBR) E3 ligases mediate ubiquitin transfer through an obligate E3- ubiquitin thioester intermediately prior to substrate ubiquitination. While RBRs share a conserved catalytic module, substrate recruitment mechanisms remain enigmatic and the relevant domains have yet to be identi...
ORGANISM(S): Homo Sapiens 
2024-07-26 | PXD030871 | panorama
ProteomicsEvaluation of a modified Orbitrap Astral Zoom prototype for quantitative proteomics - Beyond identification lists
Mass spectrometry instrumentation continues to evolve rapidly, yet quantifying these advances beyond conventional peptide and protein detections remains challenging. Here, we evaluate a modified Orbitrap Astral Zoom mass spectrometer (MS) prototype and compare its performance to the standard Orbitra...
ORGANISM(S): Homo Sapiens Gallus Gallus 
2025-10-22 | PXD064536 | panorama
ProteomicsEvaluating the Performance of the Astral Mass Analyzer for Quantitative Proteomics Using Data Independent Acquisition
We evaluate the quantitative performance of the newly released Asymmetric Track Lossless (Astral) analyzer. Using data independent acquisition, the Orbitrap Astral mass spectrometer quantifies 5 times more peptides per unit time than state-of-the-art Orbitrap mass spectrometers, which have long been...
ORGANISM(S): Homo Sapiens 
2023-09-18 | PXD042704 | panorama
UnknownDesign innovations and baseline findings in a long-term Parkinson's trial: the National Institute of Neurological Disorders and Stroke Exploratory Trials in Parkinson's Disease Long-Term Study-1.
Not available
S-EPMC3481179 | biostudies-literature
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