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ProteomicsMechanism of pharmacochaperoning in ATP-sensitive potassium channels revealed by cryo-EM
ATP-sensitive potassium (K-ATP) channels composed of a pore-forming Kir6.2 potassium channel and a regulatory ABC transporter sulfonylurea receptor 1 (SUR1) regulate insulin secretion in pancreatic beta-cells to maintain glucose homeostasis. Mutations that impair channel folding or assembly prevent ...
ORGANISM(S): Rattus norvegicus (Rat) 
2019-08-12 | PXD014498 | Pride
Pharmacological chaperones  sulfonylureas  glinides  carbamazepine  sulfonylurea receptor 1  kir6.2  structure 
ProteomicsMechanism of pharmacochaperoning in ATP-sensitive potassium channels revealed by cryo-EM
ATP-sensitive potassium (K-ATP) channels composed of a pore-forming Kir6.2 potassium channel and a regulatory ABC transporter sulfonylurea receptor 1 (SUR1) regulate insulin secretion in pancreatic beta-cells to maintain glucose homeostasis. Mutations that impair channel folding or assembly prevent ...
ORGANISM(S): Rattus norvegicus (Rat) 
2019-11-12 | PXD013873 | Pride
Pharmacological chaperones  sulfonylureas  glinides  carbamazepine  sulfonylurea receptor 1  kir6.2  structure 
UnknownRaw multi-frame images of SUR1/Kir6.2 ATP-sensitive potassium channel in the presence of Aekatperone and ATP
Not available
EMPIAR-13517 | biostudies-other
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