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Tumor sialylation controls effective anti-cancer immunity in breast cancer
Inherited defect in ST6GalNAc1 reveals roles of sialylation in intestinal homeostasis
Precise assignment of sialylation linkages at the glycopeptide level is of importance in bottom-up glycoproteomics, and is also an indispensable step to understand the function of glycoproteins in pathogen-host interactions and cancer progression. Even though some efforts have been dedicated to the ...
ORGANISM(S): Homo sapiens (Human) 
2020-04-21 | PXD016151 | Pride
Pathobiont driven antibody sialylation through IL-10 undermines vaccination
Targeting stromal cell sialylation reverses T cell mediated immunosuppression in the tumor microenvironment
Breast cancer is the most prevalent cancer among women, yet immune checkpoint inhibitors remain largely ineffective in the majority of patients. To better understand the mechanisms underlying immune evasion in breast cancer, we analyzed two independent clinical cohorts and identified a negative asso...
ORGANISM(S): Mus musculus 
2026-04-25 | GSE307142 | GEO
Inherited defect in ST6GalNAc1 reveals roles of sialylation in intestinal homeostasis
Inherited defect in ST6GalNAc1 reveals roles of sialylation in intestinal homeostasis
NANP Targeting Radio-sensitizes Glioblastoma through TNFR1 Sialylation-Driven Mesenchymal Shift

BACKGROUND: Multiple myeloma is characterized by clonal proliferation of malignant plasma cells in the bone marrow that produce monoclonal immunoglobulins. N-glycosylation changes of these monoclonal immunoglobulins have been reported in multiple myeloma, but previous studies on...

2022-04-27 | MTBLS676 | MetaboLights
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