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TranscriptomicsTNT model of neuropathic pain
In this experiment we compare the effect of tibial nerve transection on gene expression within the dorsal root ganglion (DRG) of rats.
ORGANISM(S): Rattus norvegicus 
2014-08-01 | E-MTAB-2260 | biostudies-arrayexpress
TranscriptomicsQuantification of global transcription patterns in prokaryotes using spotted microarrays
We describe an analysis, applicable to any spotted microarray dataset produced using genomic DNA as a reference, which quantifies prokaryotic levels of mRNA on a genome-wide scale. Applying this to Mycobacterium tuberculosis, we validate the technique, show a correlation between level of expression...
ORGANISM(S): Mycobacterium bovis 
2008-09-30 | E-BUGS-60 | biostudies-arrayexpress
TranscriptomicsPD1 completely suppresses the transcriptional response induced by the T cell receptor
Functional impairment of the immune response to chronic viral infections and malignancies is characterised by exhausted T cells, which do not respond to antigen. The cell surface receptor PD1 has been implicated in the maintenance of T cell exhaustion and is an attractive target for immunomodulatory...
ORGANISM(S): Homo sapiens 
2012-04-01 | E-MEXP-3410 | biostudies-arrayexpress
GenomicsFOXM1 dependent regulation of retinal pigment epithelium cell fate
The integrity of the epithelium is maintained by a complex but regulated interplay of processes that allow seamless orchestration of a proliferative state into a stably differentiated state. In this study, using stem cell derived Retinal Pigment Epithelium (RPE) cells as a model; we have investigate...
ORGANISM(S): Homo sapiens 
2015-07-24 | E-MTAB-3137 | biostudies-arrayexpress
TranscriptomicsNovel RORg inverse agonists do not modulate androgen receptor activity in prostate cancer
Work published by Wang et al. described pharmacological inhibition of RORg with an inverse agonist (SR2211) which led to a decrease in AR gene expression and a reduction in AR protein, which led to the loss of an AR gene expression signature. We have developed a novel, specific, RORg inverse agonist...
ORGANISM(S): Homo sapiens 
2019-12-31 | E-MTAB-7294 | biostudies-arrayexpress
TranscriptomicsGene expression of a variety of Huh-7 derived hepatoma cells and their susceptibility to infection by JHF1 HCV in the HCV cell culture system.
Hepatitis C virus (HCV) is a global problem. To better understand HCV infection researchers employ in vitro HCV cell-culture (HCVcc) systems that use Huh-7 derived hepatoma cells that are particularly permissive to HCV infection. A variety of hyper-permissive cells have been subcloned for this purpo...
ORGANISM(S): Homo sapiens 
2011-06-11 | E-GEOD-29889 | biostudies-arrayexpress
TranscriptomicsRNAseq of tumor samples from CT26 syngeneic mouse treated with a PI3Ka/d inhibitor (AZD8835)
PI3K inhibitors with differential selectivity to distinct PI3K isoforms have been tested extensively in clinical trials, largely to target tumor epithelial cells. PI3K signaling also regulates the immune system and inhibition of PI3Kdelta modulate the tumor immune microenvironment of pre-clinical mo...
ORGANISM(S): Mus musculus 
2019-01-08 | E-MTAB-7386 | biostudies-arrayexpress
UnknownGenetic architecture of telomere length in 462,666 UK Biobank whole-genome sequences.
Not available
S-EPMC11387196 | biostudies-literature
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