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TranscriptomicsAberrant DNA methylation at genes associated with a stem cell-like phenotype in cholangiocarcinoma tumors
Genetic abnormalities of cholangiocarcinoma (CCA) have been widely studied; however, epigenomic changes related to cholangiocarcinogenesis have been less well characterized. We have profiled the DNA methylomes of 28 primary CCA and six matched adjacent normal tissues using Infinium’s HumanMethylatio...
ORGANISM(S): Homo sapiens 
2013-01-01 | E-GEOD-38860 | biostudies-arrayexpress
TranscriptomicsGenome-wide Methylation Profiling Identifies Candidate DNA Methylation Drivers of Acquired Cisplatin Resistance in Ovarian Cancer.
Multiple DNA methylation changes have been associated with the acquisition of drug resistance; however it remains uncertain how many of these changes may represent critical DNA methylation drivers of chemoresistance. Using genome-wide DNA methylation profiling across 27,578 CpG sites on Illumina Hum...
ORGANISM(S): Homo sapiens 
2011-12-20 | E-GEOD-28647 | biostudies-arrayexpress
TranscriptomicsGene expression profiling in A2780, CP70 and CP70 following Decitabine and/or PXD101 treatment
Multiple DNA methylation changes have been associated with the acquisition of drug resistance; however it remains uncertain how many of these changes may represent critical DNA methylation drivers of chemoresistance. Using gene expression profiling method on HGU133plus2 array, we identified a total ...
ORGANISM(S): Homo sapiens 
2011-12-20 | E-GEOD-28646 | biostudies-arrayexpress
TranscriptomicsThe DNA methylomes of serous borderline tumours reveal subgroups with malignant-like or benign-like profiles
Serous borderline tumours (SBOT) are a challenging group of ovarian tumours positioned between benign and malignant disease. We have profiled the DNA methylomes of 12 low grade serous carcinoma (LGSC), 19 SBOT and 16 benign serous tumours (BST) across 27,578 CpG sites to further characterise the epi...
ORGANISM(S): Homo sapiens 
2012-12-31 | E-GEOD-40105 | biostudies-arrayexpress
TranscriptomicsGenome-wide methylation and expression profiling study identifies candidate DNA methylation drivers of acquired cisplatin resistance in ovarian cancer.
This SuperSeries is composed of the following subset Series: GSE28646: Gene expression profiling in A2780, CP70 and CP70 following Decitabine and/or PXD101 treatment GSE28647: Genome-wide methylation profiling identifies candidate DNA methylation drivers of acquired cisplatin resistance in ovarian c...
ORGANISM(S): Homo sapiens 
2011-12-20 | E-GEOD-28648 | biostudies-arrayexpress
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