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TranscriptomicsThe Small Molecule ISRIB Reverses the Effects of eIF2α Phosphorylation on Translation and Stress Granule Assembly
We recently identified ISRIB as a potent inhibitor of the integrated stress response (ISR). ISRIB renders cells resistant to the effects of eIF2α phosphorylation and enhances long-term memory in rodents (10.7554/eLife.00498). Here we show by genome-wide in vivo ribosome profiling that translation o...
ORGANISM(S): Homo sapiens 
2015-02-27 | E-GEOD-65778 | biostudies-arrayexpress
UnknownSpecific activation of the integrated stress response uncovers regulation of central carbon metabolism and lipid droplet biogenesis.
Not available
S-EPMC11436933 | biostudies-literature
UnknownSugar phosphate activation of the stress sensor eIF2B.
Not available
S-EPMC8187479 | biostudies-literature
TranscriptomicsRNA-seq of mouse embryonic fibroblasts from Eif2b1[N208Y] mice cultured with or without 2BAct
The integrated stress response (ISR) is a conserved signaling pathway triggered by a variety of insults that include ER stress, mitochondrial stress, amino acid deprivation, and viral infection. The essential stress sensor and key effector of this pathway is eIF2B, and loss-of-function mutations in ...
ORGANISM(S): Mus musculus 
2025-06-30 | E-MTAB-15247 | biostudies-arrayexpress
TranscriptomicsRNA-seq of cerebellum from Eif2b5[R191H] mice
The integrated stress response (ISR) is a conserved signaling pathway triggered by a variety of insults that include ER stress, mitochondrial stress, amino acid deprivation, and viral infection. The essential stress sensor and key effector of this pathway is eIF2B, and loss-of-function mutations in ...
ORGANISM(S): Mus musculus 
2025-06-30 | E-MTAB-15246 | biostudies-arrayexpress
TranscriptomicsSingle nuclei RNA-seq of spinal cord from Eif2b1[N208Y] mice with or without 2BAct treatment
The integrated stress response (ISR) is a conserved signaling pathway triggered by a variety of insults that include ER stress, mitochondrial stress, amino acid deprivation, and viral infection. The essential stress sensor and key effector of this pathway is eIF2B, and loss-of-function mutations in ...
ORGANISM(S): Mus musculus 
2025-07-10 | E-MTAB-15300 | biostudies-arrayexpress
TranscriptomicsSingle nuclei RNA-seq of spinal cord from Eif2b5[R191H] mice
The integrated stress response (ISR) is a conserved signaling pathway triggered by a variety of insults that include ER stress, mitochondrial stress, amino acid deprivation, and viral infection. The essential stress sensor and key effector of this pathway is eIF2B, and loss-of-function mutations in ...
ORGANISM(S): Mus musculus 
2025-07-10 | E-MTAB-15295 | biostudies-arrayexpress
TranscriptomicsRNA-seq of cerebellum, kidney, liver, lung, muscle, spinal cord, and spleen from Eif2b1[N208Y] mice with or without 2BAct treatment
The integrated stress response (ISR) is a conserved signaling pathway triggered by a variety of insults that include ER stress, mitochondrial stress, amino acid deprivation, and viral infection. The essential stress sensor and key effector of this pathway is eIF2B, and loss-of-function mutations in ...
ORGANISM(S): Mus musculus 
2025-07-10 | E-MTAB-15273 | biostudies-arrayexpress
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