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TranscriptomicsA novel extracytoplasmic function (ECF) sigma factor regulates virulence in Pseudomonas aeruginosa
Next to the two-component and quorum sensing systems, cell-surface signaling (CSS) has been recently identified as an important regulatory system in Pseudomonas aeruginosa. CSS senses signals from outside the cell and transmits them into the cytoplasm. It consists of a TonB-dependent outer membrane ...
ORGANISM(S): Pseudomonas aeruginosa 
2009-04-21 | E-GEOD-15697 | biostudies-arrayexpress
MetabolomicsEnhanced fatty acid synthesis by Sigma28 in stringent responses contributes to multidrug resistance and biofilm formation in Helicobacter pylori

The metabolism of bacteria is closely associated with antibiotic resistance, yet the role of metabolism in the resistance of Helicobacter pylori remains unclear. In this study, we conducted integrated analysis using transcriptomics and non-targeted metabolomics to investigate the metabolic change...

2024-06-26 | MTBLS9981 | MetaboLights
TranscriptomicsRole of the extracytoplasmic-function sigma Factor sigmaH in Mycobacterium tuberculosis global gene expression
Like other bacterial species, Mycobacterium tuberculosis has multiple sigma (s) factors encoded in its genome. In previously published work, we and others have shown that mutations in some of these transcriptional activators render M. tuberculosis sensitive to various environmental stresses and, in ...
ORGANISM(S): Mycobacterium tuberculosis 
2007-08-03 | E-GEOD-8689 | biostudies-arrayexpress
TranscriptomicsSigma factor E of Mycobacterium tuberculosis controls the expression of bacterial components that modulate macrophages
Sigma factor E (SigE) controls the expression of genes that are essential for Mtb virulence. In this work, we have identified the SigE regulon during infection of macrophages Our results indicate that SigE regulates the expression of genes involved in the maintenance of Mtb cell envelope integrity a...
ORGANISM(S): Mycobacterium tuberculosis 
2010-05-25 | E-GEOD-7962 | biostudies-arrayexpress
TranscriptomicsGenome-scale reconstruction of the sigma factor network in E. coli
We report the application of single-molecule-based sequencing technology for high-throughput profiling of transcription start sites for Escherichia coli under different conditions. By obtaining sequence from 5' RACE (rapid amplification of cDNA ends) followed by deep sequencing, we generated genome-...
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2014-02-05 | E-GEOD-46737 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Helicobacter pylori bearing FliK mutation to investigate the effect of the mutation on expression of eI?54 sigma factor RpoN in Helicobacter pylori
Data is also available from http://bugs.sgul.ac.uk/E-BUGS-78
ORGANISM(S): Helicobacter pylori 
2009-04-28 | E-BUGS-78 | biostudies-arrayexpress
TranscriptomicsThe Mycobacterium tuberculosis ECF sigma Factor sE: role in global gene expression and survival in macrophages
In previously published work, we identified three Mycobacterium tuberculosis sigma (s) factor genes responding to heat shock (sigB, sigE and sigH ). Two of them (sigB and sigE ) also responded to SDS exposure. As these responses to stress suggested that the s factors encoded by these genes could be ...
ORGANISM(S): Mycobacterium tuberculosis 
2007-08-02 | E-GEOD-8664 | biostudies-arrayexpress
GenomicsIdentification by ChIP-Seq of the binding sites of the extracytoplasmic function (ECF) sigma factor SigE in the genome of Streptomyces coelicolor A3(2) M600.
SigE is a sigma factor found in Streptomyces species and is the key regulator of cell envelope stress response in Streptomyces coelicolor. This ChIP-Seq experiment was carried out to determine the binding sites of SigE under conditions of cell envelope stress induced by 10 ug / ml vancomycin for 30...
ORGANISM(S): Streptomyces coelicolor A3(2) 
2019-04-24 | E-MTAB-7827 | biostudies-arrayexpress
TranscriptomicsEscherichia coli Sigma 32 ChIP-chip
Identification of Sigma 32 binding sites across the Escherichia coli genome using ChIP-chip following heat shock.
ORGANISM(S): Escherichia coli K-12 
2013-09-03 | E-MTAB-1849 | biostudies-arrayexpress
TranscriptomicsRIP-seq identification of RNAs enriched on RNA polymerase and the primary sigma factor (sigma A) in Mycobacterium smegmatis
6S RNA is a small RNA with specific secondary structure that associates with the complex of RNA polymerase (RNAP) and the primary sigma factor in majority of bacteria. In mycobacteria, Ms1 interacts with the RNAP core without the sigma factor and probably replaces 6S RNA. To identify RNAs that have ...
ORGANISM(S): Mycolicibacterium smegmatis MC2 155 
2024-02-09 | E-MTAB-11692 | biostudies-arrayexpress
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