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MetabolomicsCell Atlas and Novel Signal Processing Strategy in Primate Insular Cortex

The anterior insular cortex (AIC) is a critical hub integrating exteroceptive and interoceptive information into high-order cognition, yet its neural basis remains incompletely understood. Here, by combining whole-cell-based single-cell transcriptomics with Patch-seq recordings, we resolved and c...

2026-02-28 | MTBLS13927 | MetaboLights
MetabolomicsDetection Limits of Blood Metabolites at Physiological Concentrations Using Benchtop 1H NMR

Commercial low-field (LF) magnetic resonance spectroscopy (MRS) offers a route to rapid and repeated \textit{in vivo} metabolite tracking, however its sensitivity and interpretability at physiological concentrations remain underexplored. Here we evaluate the performance of an 80 MHz benchtop nucl...

2025-12-29 | MTBLS6262 | MetaboLights
MetabolomicsA blood-based metabolic signature for earlier detection of lung cancer

Metabolomic profiling was applied to 1,259 sera collected within five years of a lung cancer diagnosis and 8,470 non-case sera from ever-smoker participants in the Prostate Lung Colorectal and Ovarian (PLCO) Study to identify metabolic signatures for the earlier detection of lung cancer. We devel...

2026-08-20 | MTBLS15406 | MetaboLights
MetabolomicsIntegrating genomics and multi‐platform metabolomics enables metabolite QTL detection in breeding‐relevant apple germplasm
Apple (Malus × domestica) has commercial and nutritional value, but breeding constraints of tree crops limit varietal improvement. Marker-assisted selection minimizes these drawbacks, but breeders lack applications for targeting fruit phytochemicals. To understand genotype-phytochemical associations...
2021-09-21 | MTBLS2327 | MetaboLights
MetabolomicsCoupled Mass-Spectrometry-Based Lipidomics Machine Learning Approach for Early Detection of Clear Cell Renal Cell Carcinoma

A discovery-based lipid profiling study of serum samples from a cohort that included patients with clear cell Renal Cell Carcinoma (ccRCC) stage I, II, III, and IV (n=112) and controls (n=52) was performed using ultraperformance liquid chromatography coupled to quadrupole-time-of-flight mass spec...

2020-11-20 | MTBLS1839 | MetaboLights
MetabolomicsMetabolomics of Solanum lycopersicum infected by Phytophthora infestans leads to Late blight detection and reveals metabolic differences in infection times
Tomato crops suffer attacks of various pathogens that cause large production losses. Late blight caused by Phytophthora infestans is a devastating disease in tomatoes because of its difficultly to control. Here, we applied metabolomics based on liquid chromatography–mass spectrometry (LC-MS) and met...
2019-01-24 | MTBLS618 | MetaboLights
MetabolomicsRapid detection of Staphylococcus aureus and Streptococcus pneumoniae by real-time analysis of volatile metabolites
Early detection of pathogenic bacteria is needed for rapid diagnostics allowing adequate and timely treatment of infections. In this study, we show that Secondary Electro-Spray Ionization-High Resolution Mass Spectrometry (SESI-HRMS) can be used as a diagnostic tool for rapid detection of bacterial ...
2022-07-06 | MTBLS5085 | MetaboLights
MetabolomicsDetection of adulteration in Iranian saffron samples by 1H NMR spectroscopy and multivariate data analysis techniques
Introduction: The high market value of saffron (Crocus sativus L.) has made it an attractive candidate for adulteration. Safflower (Carthamus tinctorius L.) and tartrazine are among the most common herbal and synthetic foreign materials that may be added to pure saffron for the purpose of adulterati...
2017-07-20 | MTBLS331 | MetaboLights
MetabolomicsMetabolic Footprinting of a Clear Cell Renal Cell Carcinoma in vitro Model for Human Kidney Cancer Detection
A protocol for harvesting and extracting extracellular metabolites from an in vitro model of human renal cell lines was developed to profile the exometabolome by means of a discovery-based metabolomics approach using ultraperformance liquid chromatography coupled to quadrupole-time-of-flight mass sp...
2018-11-14 | MTBLS737 | MetaboLights
TranscriptomicsA comprehensive assessment of array-based platforms and calling algorithms for detection of copy number variants (Illumina_650Y)
Systematic evaluation of eleven array platforms commonly used for CNV detection to address parameters of quality and CNV calling. 18 Samples
ORGANISM(S): Homo sapiens 
2011-06-30 | E-GEOD-28102 | biostudies-arrayexpress
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