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MetabolomicsAlterations in SHH signal transduction introduce a state of hypometabolism in sporadic Parkinson's disease
Not available
ORGANISM(S): Homo sapiens 
ST002389 | MetabolomicsWorkbench
ProteomicsStructural Analysis of Hippocampal Kinase Signal Transduction
Kinases are a major clinical target for human diseases. Identifying the proteins that interact with kinases in vivo will provide information on unreported substrates and will potentially lead to more specific methods for therapeutic kinase regulation. Here, endogenous immunoprecipitations of evolu...
ORGANISM(S): Rattus Norvegicus (ncbitaxon:10116) 
2018-05-23 | MSV000082390 | MassIVE
TranscriptomicsNutrient-Regulated Antisense and Intragenic RNAs Modulate a Signal Transduction Pathway
The budding yeast Saccharomyces cerevisiae alters its gene expression profile in response to a change in nutrient availability. The PHO-system is a well-studied case in the transcriptional regulation responding to nutritional changes in which a set of genes (PHO genes) is expressed to activate phosp...
ORGANISM(S): Saccharomyces cerevisiae 
2008-12-23 | E-GEOD-13350 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation of activated yeast signal transduction protein kinases
Cellular signal transduction pathways modify gene expression programs in response to changes in the environment, but the mechanisms by which they regulate populations of genes under their control are not entirely understood. We present evidence that most mitogen-activated protein kinases and protei...
ORGANISM(S): Saccharomyces cerevisiae 
2006-07-28 | E-TABM-98 | biostudies-arrayexpress
MetabolomicsCitrate serves as a signal molecule to modulate carbon metabolism and iron homeostasis in Staphylococcus aureus

Pathogenic bacteria's metabolic adaptation for survival and proliferation within hosts is a crucial aspect of bacterial pathogenesis. Here, we demonstrate that citrate, the first intermediate of the tricarboxylic acid (TCA) cycle, plays a key role as a regulator of gene expression in Staphylococc...

2024-04-26 | MTBLS4276 | MetaboLights
TranscriptomicsThe Two-component Signal Transduction System CopRS of Corynebacterium glutamicum is Required for Adaptation to Copper-excess Stress
Copper is an essential cofactor for many enzymes but at high concentrations it is toxic for the cell. Copper ion concentrations ≥50 µM inhibited growth of Corynebacterium glutamicum. The transcriptional response to 20 µM Cu2+ was studied using DNA microarrays and revealed 26 genes that showed a ≥3-f...
ORGANISM(S): Corynebacterium glutamicum ATCC 13032 
2011-09-04 | E-GEOD-27510 | biostudies-arrayexpress
TranscriptomicsTranscriptional analysis of signal transduction-related genes in experimental models of HER-2/neu-derived epithelial and mesenchymal tumors
Transcriptional expression of a restricted set of cancer signal transduction-related gesen were comparatively quantified in HER2/neu transgenic mammary tumors, mesenchymal and epithelial tumor cell lineages, both estabilished from HER-2/neu transgenic tumors, and syngeneic mesenchymal stem cells. In...
ORGANISM(S): Mus musculus 
2010-07-03 | E-GEOD-22663 | biostudies-arrayexpress
ModelsMacNamara2012 - Signal transduction
MacNamara2012 - Signal transduction A toy model of signal tranduction to illustrate how different logic formalizms (Boolean, fuzzy logic and differential equations) treat state and time, is described here. This model was generated from the PKN-ToyPB.sif file available in...
2005-01-01 | MODEL1305240000 | BioModels
TranscriptomicsInterfering with Proximal TLR4 to NF-kappaB Signal Transduction in Human Monocytes
This study investigated the global effect of carbon monoxide (CO) gas (250 ppm) on LPS- induced gene expression in THP-1 cells. CO predominantly suppresses LPS-induced gene response. Of the CO-suppressed genes, 18% were transcription factors and most others were cytokines, chemokines and immune resp...
ORGANISM(S): Homo sapiens 
2010-06-08 | E-GEOD-16193 | biostudies-arrayexpress
TranscriptomicsStudies of target genes for signal transduction pathways (using a Ras1-, a Cdc42- and a Gap1-mutant) in the basidiomycete Schizophyllum commune.
Transcriptome changes associated with signal transduction mutants were analysed in order to identify targets of the distinct pathways of Ras1, Cdc42 and Gap1. Two monokaryons (12-43 and 4-39), a dikaryon (W22 x 12-43), a constitutive active Ras1 mutant (T2G12V, monokaryon), a Cdc42 mutant (G12V, mon...
ORGANISM(S): Schizophyllum commune 
2013-02-01 | E-GEOD-43965 | biostudies-arrayexpress
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