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TranscriptomicsPOLRMT regulates the switch between replication-primer formation and gene expression of mammalian mtDNA
Mitochondria are vital in providing cellular energy via their oxidative phosphorylation system, which requires the coordinated expression of genes encoded by both the nuclear and mitochondrial genomes (mtDNA). Transcription of the circular mammalian mtDNA depends on a single mitochondrial RNA polyme...
ORGANISM(S): Mus musculus 
2016-08-05 | E-GEOD-83368 | biostudies-arrayexpress
ProteomicsMitochondrial gene expression is required for platelet function and blood clotting
Platelets are anucleate blood cells that contain mitochondria and regulate blood clotting in response to injury. Mitochondria contain their own gene expression machinery which relies on nuclear encoded factors for the biogenesis of the oxidative phosphorylation (OXPHOS) system to produce energy, ion...
ORGANISM(S): Mus musculus (Mouse) 
2023-11-01 | PXD045688 | Pride
Megakaryocytes Mitochondria Platelets 
TranscriptomicsHierarchical RNA processing is rate limiting for mitochondrial ribosome assembly
In animals the organization of the compact mitochondrial genome and lack of introns have necessitated a unique mechanism for RNA processing. To date the regulation of mitochondrial RNA processing and its importance for ribosome biogenesis and energy metabolism are not clear. To understand the in viv...
ORGANISM(S): Mus musculus 
2016-08-04 | E-GEOD-83471 | biostudies-arrayexpress
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