Silam - OmicsDI

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Proteomics (19)
Unknown (13)
Genomics (1)

Organisms

Schizosaccharomyces pombe (16)
Sinorhizobium meliloti BL225C (16)
Sus scrofa domesticus (16)
Saccharomyces cerevisiae (16)
Staphylococcus aureus (16)
Rattus norvegicus (16)
Escherichia coli (16)
Methylohalobius crimeensis 10Ki (16)
Homo sapiens (16)
Shigella flexneri (16)
Allexis (16)
Shigella (16)
Zea mays (16)
Meleagris gallopavo (16)
Medicago truncatula (16)
Listeria monocytogenes (16)
Callinectes sapidus (16)
Bos taurus (16)
Entamoeba histolytica HM-1:IMSS-A (16)
Drosophila melanogaster (16)
Solanum tuberosum (16)
Arabidopsis thaliana (16)
Leishmania major strain Friedlin (16)
Mus musculus (16)
Bombyx mori (15)
Human immunodeficiency virus 1 (15)
Oryza sativa Indica Group (15)
Ostreococcus tauri (15)
Vitis vinifera (15)
Mus musculus (1)

Repository

pride (16)
MassIVE (3)
ENA (1)

Tissue

Brain (10)
Kidney (4)
Heart (3)
Liver (3)
Lung (2)
Thymus (2)
Corpus callosum (1)
Gastrointestinal mucosa (1)
Cardiovascular system (1)
Aorta (1)
Primary neuron (1)
Intestine (1)
Adipose tissue (1)
Skeletal muscle (1)
Fibroblast (1)
Epithelial cell (1)
Cell culture (1)

Disease

Parkinson's disease (3)
Inflammatory bowel disease (1)
Bacterial sepsis (1)

Technology Type

Mass Spectrometry (16)
Shotgun proteomics (13)
Bottom-up proteomics (2)
Gel-based experiment (1)
Data-dependent acquisition (1)

Instrument Platform

LTQ Orbitrap Elite (2)
Q-Exactive( Thermo fisher) (1)
LTQ Velos (1)
Orbitrap Fusion (1)

Publication Date

2018 (6)
2023 (2)
2019 (2)
2021 (2)
2020 (2)
2017 (2)
2026 (1)
2022 (1)
2012 (1)

First Public Date

2022 (1)

Modification

Not available (1)

Release Date

2017 (2)
2013 (2)
2025 (1)
2020 (1)
2018 (1)
2016 (1)
2015 (1)
2014 (1)
2012 (1)
2011 (1)
2008 (1)

Lab affiliation

Biochemistry and Molecular Biophysics Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA Children's Hospital of Philadelphia Research Institute, Philadelphia, PA 19104, USA. (1)
The Solomon H. Snyder Department of Neuroscience Johns Hopkins University School of Medicine USA (1)
Biochemistry and Molecular Biophysics Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA (1)
Biochemistry and Molecular Biophysics Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Children's Hospital of Philadelphia Research Institute, Philadelphia, PA 19104, USA. (1)
Center for Neuroscience Research Children's National Medical Center 111 Michigan Avenue N.W., M7631 Washington, DC 20010-2970 Phone: +1-202-476-4279 Fax: +1-202-476-4988 e-mail: MTorii@childrensnational.org (1)
Department of Neurology Institute for Cell Engineering Johns Hopkins University School of Medicine (1)
Department of Molecular and Experimental Medicine, Department of Chemical Physiology, The Scripps Research Institute, USA (1)
1School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore, 637551, Singapore (1)
Cell Signaling and Immunology, School of Life Science, University of Dundee, Dundee. United Kingdom (1)
MRC Laboratory of Molecular Biology (1)
Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA Department of Physiology, University of California, San Francisco, San Francisco, CA Chan Zuckerberg Biohub, San Francisco, CA (1)
IMDEA-Food Research Institute, +Pec Proteomics, Campus of International Excellence UAM+CSIC, Old Cantoblanco Hospital, 8 Crta. Canto Blanco, Madrid, 28049, Spain. (1)
Biochemistry and Molecular Biology, University of British Columbia, Canada (1)
Michael Smith Laboratories, Biochemistry and Molecular Biology, University of British Columbia, Canada (1)
Department of Laboratory Medicine and Pathology, Mayo Clinic, USA (1)
University of Pittsburgh (1)

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Differential proteomic analysis of mammalian tissues using SILAM.

Not available

S-EPMC3024400 | biostudies-literature

Pulsed SILAM Reveals In Vivo Dynamics of Murine Brain Protein Translation.

Not available

S-EPMC7301365 | biostudies-literature

The use of urinary and kidney SILAM proteomics to monitor kidney response to high dose morpholino oligonucleotides in the mdx mouse.

Not available

S-EPMC4512206 | biostudies-literature

In vivo murine brain protein synthesis uncover the molecular physiological process in brain

Identification of proteins that are synthesised de novo in response to specific microenvironmental cues is critical for understanding the molecular mechanisms, which underpin vital physiological processes and pathologies. Here, we report that a brief period of pulsed SILAM (Stable Isotope Labeling o...

ORGANISM(S): Mus musculus (Mouse)

2020-06-23 | PXD013502 | Pride

Identification and quantification of human postmortem frontal cortex proteome with a SILAM mouse brain standard

Prefrontal cortex tissue slices from a cognitively and neurpathologically normal human subject were obtained from the University of Pennsylvania (UPenn) Brain Bank. 300-350 mg grey matter was homogenized in 1.5 ml solution A (0.32 M sucrose, 1mM MgCl2 and 0.1mM CaCl2) with a Teflon pestle. ~100 ?l ...

ORGANISM(S): Homo sapiens (Human)

2012-12-10 | PXD000004 | Pride

Human Brain Silam Lc-ms/ms

Tracking brain palmitoylation change: predominance of glial change in a mouse model of Huntington's disease.

Not available

S-EPMC3880188 | biostudies-literature

Multiplexed proteome analysis with neutron-encoded stable isotope labeling in cells and mice.

Not available

S-EPMC5920564 | biostudies-literature

Sex and experience dependent regulation of synaptic protein turnover

Synaptic transmission can be carefully tuned through plasticity mechanisms that regulate synaptic strength, structure, and number. In vivo measurements demonstrate remarkable spine dynamics, with subsets of synapses persisting for months. This correlates with the extreme longevity of certain memorie...

ORGANISM(S): Mus musculus (Mouse)

2026-09-07 | PXD065808 | Pride

Silam Protein turnover Lc-ms/ms

DNA Adduct Profiles Predict in Vitro Cell Viability after Treatment with the Experimental Anticancer Prodrug PR104A.

Not available

S-EPMC5362746 | biostudies-literature

Do Perineuronal nets stabilize the engram of a synaptic circuit?

SILAM experiment testing brain protein turnover. With an emphasis on PNN and synaptic proteins.

ORGANISM(S): Mus <mouse, Genus> (ncbitaxon:10088)

2019-10-01 | MSV000084400 | MassIVE

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