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UnknownGenome-wide association study reveals novel genetic loci: a new polygenic risk score for mitral valve prolapse.

Aims

Mitral valve prolapse (MVP) is a common valvular heart disease with a prevalence of >2% in the general adult population. Despite this high incidence, there is a limited understanding of the molecular mechanism of this disease, and no medical therapy is available for this disease. We aim...
S-EPMC9649914 | biostudies-literature
UnknownLarge-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation.
Atrial fibrillation affects more than 33 million people worldwide and increases the risk of stroke, heart failure, and death. Fourteen genetic loci have been associated with atrial fibrillation in European and Asian ancestry groups. To further define the genetic basis of atrial fibrillation, we perf...
S-EPMC5585859 | biostudies-literature
UnknownMulti-ethnic genome-wide association study for atrial fibrillation.
Atrial fibrillation (AF) affects more than 33 million individuals worldwide1 and has a complex heritability2. We conducted the largest meta-analysis of genome-wide association studies (GWAS) for AF to date, consisting of more than half a million individuals, including 65,446 wi...
S-EPMC6136836 | biostudies-literature
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