Multi-ethnic genome-wide association study for atrial fibrillation.

ABSTRACT: Atrial fibrillation (AF) affects more than 33 million individuals worldwide¹ and has a complex heritability². We conducted the largest meta-analysis of genome-wide association studies (GWAS) for AF to date, consisting of more than half a million individuals, including 65,446 with AF. In total, we identified 97 loci significantly associated with AF, including 67 that were novel in a combined-ancestry analysis, and 3 that were novel in a European-specific analysis. We sought to identify AF-associated genes at the GWAS loci by performing RNA-sequencing and expression quantitative trait locus analyses in 101 left atrial samples, the most relevant tissue for AF. We also performed transcriptome-wide analyses that identified 57 AF-associated genes, 42 of which overlap with G

SUBMITTER: Roselli C 

PROVIDER: S-EPMC6136836 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature