Genetic risk factors for postoperative atrial fibrillation-a nationwide genome-wide association study (GWAS).

ABSTRACT:

Background

Atrial fibrillation (AF) is a major cause of morbidity with a high prevalence among the elderly and has an established genetic disposition. Surgery is a well-known risk factor for AF; however, it is currently not recognized how much common genetic variants influence the postoperative risk. The purpose of this study was to identify Single Nucleotide Polymorphisms associated with postoperative AF.

Methods

The UK Biobank was utilized to conduct a Genome-Wide Association Study (GWAS) to identify variants associated with AF after surgery. An initial discovery GWAS was performed in patients that had undergone surgery with subsequent replication in a unique non-surgical cohort. In the surgical cohort, cases were defined as newly diagnosed AF within 30 days after surgery.

SUBMITTER: Christensen MA 

PROVIDER: S-EPMC10315824 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature